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Table 1 IC50 values of primary leukemia cells from patients with leukemia to pristimerin.

From: Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

Patient no.

Diagnosis

Imatinib sensitive

Imatinib resistance

IC50 (nM)

1

CML

 

×

578

2

CML

×

 

6.28

3

CML

×

 

326

4

CML

×

 

186

5

CML

×

 

210

6

JMML

  

326

7

ALL

  

205

  1. Note: CML, chronic myelogeneous leukemia; JMML, juvenile myelomonocytic leukemia; ALL, acute lymphoid leukemia.
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Molecular Cancer

ISSN: 1476-4598