NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations

Table 2 Summary of PANTHER pathway enrichment analysis for transcripts correlated with NOTCH2 in the NCI-60 set of cell lines

PANTHER category^a		No. of genes in reference list	Observed no. of genes in category	Expected no. of genes in category	Over(+)/under(-) representation	p-value^b
*For genes with positive correlation with NOTCH2 expression*
BP00285	Cell structure and motility	990	65	27.7	+	6.96 × 10^-9
P00034	Integrin signalling pathway	217	26	6.1	+	1.87 × 10^-7
MF00091	Cytoskeletal protein	698	47	19.5	+	1.22 × 10^-6
BP00125	Intracellular protein traffic	892	51	25.0	+	4.59 × 10^-5
MF00261	Actin binding cytoskeletal protein	342	29	9.6	+	3.46 × 10^-5
*For genes with negative correlation with NOTCH2 expression*
MF00042	Nucleic acid binding	2214	187	100.1	+	1.88 × 10^-17
BP00031	Nucleoside, nucleotide and nucleic acid metabolism	2837	203	128.3	+	1.20 × 10^-10
BP00047	Pre-mRNA processing	264	35	11.9	+	4.74 × 10^-6
BP00048	mRNA splicing	196	29	8.9	+	1.04 × 10^-5

^aPANTHER accession number for pathway (P), biological process (BP), or molecular function (MF) http://www.pantherdb.org/.
^bp-values of binomial test with Bonferroni correction for multiple testing.

ISSN: 1476-4598