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Figure 4 | Molecular Cancer

Figure 4

From: Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence

Figure 4

Determination of caspases activity in HeLa, SiHa and HaCaT cells after in vitro treatment with Pentoxifylline (PTX) or Adriamycin (ADR) either alone or in combination. Cell cultures were treated with PTX (8 mM) or ADR (1 μM) or their combination (PTX + ADR), 24 hours later the cells were harvested and caspase activity was determined measuring caspase-cleaved cytokeratin 18 neo-epitope M30 by flow cytometry (M30 CytoDeath™ Biotin Kit). The results represent the percentage of caspase activity ± standard deviation of three independent experiments carrier out in triplicate. Statistical analysis Student "t" test. (*) p < 0.001 vs untreated control cells (CT). (•) p < 0.001 vs PTX or ADR groups.

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Molecular Cancer

ISSN: 1476-4598