Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence

Table 1 Viability of HeLa, SiHa or HaCaT cells after in vitro exposition to Pentoxifylline and Adriamycin

CELL LINE PERCENTAGE OF CELLULAR VIABILITY ± SD
GROUP	HeLa	SiHa	HaCaT
PTX 8 mM	63.6 ± 2.1	57.8 ± 1.0	74.1 ± 1.0
ADR 1 μM	88.6 ± 3.0	70.1 ± 2.0	95.0 ± 7.6
PTX + ADR	40.2 ± 1.0	33.0 ± 1.2	78.5 ± 1.1

SD = standard deviation, Pentoxifylline = PTX, Adriamycin = ADR. Cultures cells were treated with PTX or ADR or their combination, 24 hours later the cells were harvested and cell viability was determined spectrophotometrically at 450 nm using WST-1 kit. The results are reported in percentage of cell viability as compared to untreated control groups respectively considered as 100% and the values represent the mean SD of three independent experiments.

ISSN: 1476-4598