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Table 1 Genomic aberrations and targeted genes observed in CLL patients resistant to fludarabine.

From: Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia

Genomic aberrations

Type of aberration

Targeted gene(s)

idic(3q)

Deletion 3p

XPC, RAD18, PCAF

 

Gain 3q

BCL6, FAIM, p63

7q21, 7q36 1

Gain

MDR family genes

idic(8q)

Deletion 8p

TNFRSF10 family genes

 

Gain 8q

MYC

9p24p21 2

Deletion

JAK2, p16INK4, CDKN2B, SMARCA2

11q23

Deletion

ATM

12p13.31p12

Deletion

p27

13q14.2q14.3

Deletion

DLEU genes, Rb, miR-15a, miR-16-1

15q15q26

Gain

MGA, PML, BLM, cyclin B2, and 53BP1

idic(17q)

Deletion 17p

p53, MNT

 

Gain 17q

STAT3, SPOP, RAD51L3, RARA, RDM1

  1. 1 These aberrations were observed only in patient CLL-6R
  2. 2 This aberration was observed only in patient CLL-3R