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Table 2 Gene set enrichment analysis (GSEA) of CLL B cells from fludarabine-sensitive and -resistant patients

From: Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia

Function/Pathway Gene sets enriched in sensitive patients Size NES NOM p-val
p53 response STRESS_ARSENIC_SPECIFIC_UP 6 1.76 0.002
  P53PATHWAY 6 1.61 0.004
  HSA04115_P53_SIGNALING_PATHWAY 13 1.62 0.006
  P53GENES_ALL 9 1.53 0.021
  P53_BRCA1_UP 5 1.50 0.030
  STRESS_P53_SPECIFIC_UP 5 1.44 0.031
  KANNAN_P53_UP 9 1.51 0.032
DNA damage response DNA_DAMAGE_SIGNALING 13 1.69 0.008
  UVC_TTD-XPCS_COMMON_DN 8 1.69 0.014
  CIS_XPC_DN 10 1.73 0.017
DNA repair, cell cycle, apoptosis BLEO_HUMAN_LYMPH_HIGH_4HRS_UP 9 1.59 0.028
BAFF/APRIL receptor MOREAUX_TACI_HI_VS_LOW_UP 8 1.45 0.023
hTERT-regulated genes SMITH_HTERT_DN 5 1.57 0.028
  ROTH_HTERT_DIFF 7 1.48 0.049
NF-KB signaling HINATA_NFKB_UP 6 1.53 0.032
Cell death APOPTOSIS 6 1.55 0.034
  BRENTANI_DEATH 6 1.55 0.034
  APOPTOSIS_GENMAPP 5 1.56 0.035
Cell cycle CELL_CYCLE_KEGG 6 1.52 0.044
  CELL_CYCLE 6 1.52 0.044
  TAKEDA_NUP8_HOXA9_16D_DN 11 1.43 0.045
Function/Pathway Gene sets enriched in resistant patients Size NES NOM p-val
T lymphocyte proliferation GOLDRATH_HP 14 1.61 0.008
EGR2-regulated genes LE_MYELIN_UP 6 1.58 0.009
Genes involved in cholera infection HSA05110_CHOLERA_INFECTION 5 1.63 0.023
Myeloma cell growth and survival CHAUHAN_2ME2 5 1.50 0.042
DNA and RNA metabolism WERNER_FIBRO_DN 5 1.45 0.059
p53 response, anti-apoptosis, DNA repair UVB_SCC_DN 6 1.39 0.086
Myc-regulated genes MYC_ONCOGENIC_SIGNATURE 8 1.37 0.061
Functions of mature T lymphocytes LEE_TCELLS2_UP 46 1.27 0.084
Hematopoeitic stem cell genes BYSTRYKH_HSC_TRANS_GLOCUS 29 1.38 0.070
APC-regulated genes SANSOM_APC_LOSS5_UP 10 1.47 0.084
  1. NES Normalized Enrichment Score, NOM p-val Nominal p-value