Figure 3

Analysis of miR-21 knockdown on the chemosensitivity profiles of PCa cells. (A) Growth inhibition curves of untreated (black triangle), LNAScr (black circle)- or LNA21 (white circle)-transfected PCa cells exposed to increasing concentrations of cisplatin or taxol. Data are reported as percentage of growing cells compared to untreated controls and represent mean values ± SD of at least three independent experiments. (B) Quantification of cells with an apoptotic nuclear morphology by propidium iodide staining of PCa cells transfected with LNAScr (white bars) or LNA21 (grey bars) and exposed to IC₅₀ of cisplatin or taxol. Data are reported as the average (± SD) of the percentage of apoptotic cells in the overall cell population.