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Figure 2 | Molecular Cancer

Figure 2

From: Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Figure 2

Activation of HER family members rescues PHA-impaired anchorage-independent growth ability. (A,B) GTL16 cells were grown in agar for 2 weeks and the amount of viable cells grown in colonies was evaluated with the Alamar Blue dye. MET inhibition with PHA (250 nM) resulted in impairment of cell ability to grow in an anchorage-independent manner compared to untreated cells, considered as 100%. Stimulation with EGF (50 ng/ml), or HRG1-β1 (10 ng/ml), rescued the ability of PHA-treated cells to form colonies (*P < 0,05; *** P < 0,001).

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