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Figure 1 | Molecular Cancer

Figure 1

From: Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

Figure 1

Morphology of MDA-MB-231-derived subclones in 3D organotypic culture. Cells were plated onto a layer of growth factor-reduced Matrigel® matrix as described in Materials and Methods. Confocal microscopy images of 9 day-old 3D cultures labeled with Alexa-488-phalloidin were obtained. Colonies of early (SCP2TR and SCP25TR) and post-dormant (2860TR and 3847TR) bone-tropic subclones displayed a mass-like and grape-like morphology, respectively [46]. In contrast, the two lung-tropic subclones (4175TR and 4173) exhibited a stellate invasive phenotype [46].

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