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Figure 5 | Molecular Cancer

Figure 5

From: MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

Figure 5

Impact of anti-miRNAs on MEG-01 fludarabine sensitivity. Caspase 3/7 activity after anti-miR-21, 222, 148a treatment of MEG-01 cells, in absence or presence of fludarabine (1 μM). LNA-anti-miR-21 and anti-miR-222, but not anti-miR-148a, were able to induce increase apoptosis in MEG-01 cells, which harbor a mutant p53 protein. The inhibition of miR-21 and miR-222 sensitizes the cells to fludarabine action, leading to an increased caspase activation when fludarabine 1 μM is added after 24 hours.

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