Figure 5
From: MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
Impact of anti-miRNAs on MEG-01 fludarabine sensitivity. Caspase 3/7 activity after anti-miR-21, 222, 148a treatment of MEG-01 cells, in absence or presence of fludarabine (1 μM). LNA-anti-miR-21 and anti-miR-222, but not anti-miR-148a, were able to induce increase apoptosis in MEG-01 cells, which harbor a mutant p53 protein. The inhibition of miR-21 and miR-222 sensitizes the cells to fludarabine action, leading to an increased caspase activation when fludarabine 1 μM is added after 24 hours.