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Table 4 Pathways significantly enriched among the genes modulated by Fludarabine in sensitive and refractory CLLs

From: MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

 

Significant pathways in responder patients

Significant pathways in non responder patients

Pathway

Number of Entities

Matched with Technology

Matched with EntityList

pValue

Number of Entities

Matched with Technology

Matched with EntityList

pValue

G1/S DNA Damage Checkpoints

11

2

2

5.40E-04

11

2

1

4.64E-02

Stabilization of p53

5

2

2

5.78E-04

5

2

1

5.08E-02

p53-Dependent G1 DNA Damage Response

7

2

2

5.78E-04

7

2

1

5.08E-02

p53-Dependent G1/S DNA damage checkpoint

7

2

2

5.78E-04

7

2

1

5.08E-02

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

9

3

2

1.70E-03

    

p53 signaling pathway

14

11

3

1.98E-03

    

atm signaling pathway

17

13

3

3.31E-03

17

13

2

4.28E-02

Class I PI3K signaling events

456

181

12

4.91E-03

456

181

10

1.43E-02

Aurora A signaling

117

43

5

5.49E-03

    

hypoxia and p53 in the cardiovascular system

27

16

3

6.13E-03

    

tumor suppressor arf inhibits ribosomal biogenesis

27

16

3

6.13E-03

    

inhibition of cellular proliferation by gleevec

21

17

3

6.67E-03

21

17

2

5.93E-02

nfkb activation by nontypeable hemophilus influenzae

29

17

3

6.67E-03

29

17

2

5.93E-02

TRAIL signaling pathway

641

246

15

7.54E-03

641

246

15

3.24E-03

IL2 signaling events mediated by PI3K

110

33

5

7.73E-03

    

Activation of BH3-only proteins

13

6

2

8.12E-03

    

cell cycle: g2/m checkpoint

24

19

3

1.01E-02

24

19

2

8.48E-02

Signaling events mediated by HDAC Class III

44

21

3

1.22E-02

44

21

2

8.62E-02

repression of pain sensation by the transcriptional regulator dream

15

8

2

1.38E-02

    

mapkinase signaling pathway

41

39

4

1.40E-02

41

39

3

7.84E-02

rna polymerase iii transcription

10

8

2

1.47E-02

    

Signaling events regulated by Ret tyrosine kinase

131

40

4

1.61E-02

    

Signaling by Aurora kinases

162

59

5

1.76E-02

    

IL2-mediated signaling events

184

64

6

1.87E-02

184

64

5

6.96E-02

Role of Calcineurin-dependent NFAT signaling in lymphocytes

133

64

5

1.88E-02

    

oxidative stress induced gene expression via nrf2

16

10

2

2.15E-02

    

G(s)-alpha mediated events in glucagon signalling

5

1

1

2.33E-02

    

Activation of PUMA and translocation to mitochondria

1

1

1

2.41E-02

    

Activation of NOXA and translocation to mitochondria

1

1

1

2.41E-02

    

G2/M DNA damage checkpoint

7

1

1

2.41E-02

    

Intrinsic Pathway for Apoptosis

32

12

2

3.05E-02

    

agrin in postsynaptic differentiation

23

13

2

3.55E-02

    

cadmium induces dna synthesis and proliferation in macrophages

37

13

2

3.55E-02

    

Plasma membrane estrogen receptor signaling

547

217

11

3.66E-02

547

217

9

8.14E-02

il-2 receptor beta chain in t cell activation

42

31

3

3.77E-02

    

hypoxia-inducible factor in the cardivascular system

26

14

2

4.08E-02

    

BMP receptor signaling

329

163

9

4.33E-02

329

163

8

4.54E-02

Class I PI3K signaling events mediated by Akt

160

55

4

4.35E-02

    

rho-selective guanine exchange factor akap13 mediates stress fiber formation

11

2

1

4.60E-02

11

2

1

4.64E-02

FasL/CD95L signaling

6

2

1

4.75E-02

    

alk in cardiac myocytes

20

15

2

4.93E-02

20

15

3

6.12E-03

role of mef2d in t-cell apoptosis

31

15

2

5.22E-02

31

15

4

4.38E-04

TNF receptor signaling pathway

495

213

11

7.61E-02

495

213

11

3.77E-02

integrin signaling pathway

28

21

2

9.19E-02

28

21

3

1.42E-02

FAS signaling pathway (CD95)

    

63

26

5

2.99E-03

endocytotic role of ndk phosphins and dynamin

    

22

6

2

7.76E-03

BCR signaling pathway

    

94

52

5

8.63E-03

Integrins in angiogenesis

    

107

38

4

1.18E-02

Alkaloid biosynthesis II

    

45

21

3

1.81E-02

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling

    

39

24

3

1.81E-02

t cell receptor signaling pathway

    

44

23

3

1.81E-02

links between pyk2 and map kinases

    

39

24

3

2.02E-02

dicer pathway

    

4

1

1

2.57E-02

AndrogenReceptor

    

98

93

6

3.29E-02

Osteopontin-mediated events

    

48

13

2

3.62E-02

TCR signaling in naïve CD8+ T cells

    

188

72

5

3.66E-02

fas signaling pathway (cd95)

    

24

14

2

4.16E-02

Ceramide signaling pathway

    

90

55

5

4.48E-02

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Molecular Cancer

ISSN: 1476-4598