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Table 4 Pathways significantly enriched among the genes modulated by Fludarabine in sensitive and refractory CLLs

From: MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

  Significant pathways in responder patients Significant pathways in non responder patients
Pathway Number of Entities Matched with Technology Matched with EntityList pValue Number of Entities Matched with Technology Matched with EntityList pValue
G1/S DNA Damage Checkpoints 11 2 2 5.40E-04 11 2 1 4.64E-02
Stabilization of p53 5 2 2 5.78E-04 5 2 1 5.08E-02
p53-Dependent G1 DNA Damage Response 7 2 2 5.78E-04 7 2 1 5.08E-02
p53-Dependent G1/S DNA damage checkpoint 7 2 2 5.78E-04 7 2 1 5.08E-02
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 3 2 1.70E-03     
p53 signaling pathway 14 11 3 1.98E-03     
atm signaling pathway 17 13 3 3.31E-03 17 13 2 4.28E-02
Class I PI3K signaling events 456 181 12 4.91E-03 456 181 10 1.43E-02
Aurora A signaling 117 43 5 5.49E-03     
hypoxia and p53 in the cardiovascular system 27 16 3 6.13E-03     
tumor suppressor arf inhibits ribosomal biogenesis 27 16 3 6.13E-03     
inhibition of cellular proliferation by gleevec 21 17 3 6.67E-03 21 17 2 5.93E-02
nfkb activation by nontypeable hemophilus influenzae 29 17 3 6.67E-03 29 17 2 5.93E-02
TRAIL signaling pathway 641 246 15 7.54E-03 641 246 15 3.24E-03
IL2 signaling events mediated by PI3K 110 33 5 7.73E-03     
Activation of BH3-only proteins 13 6 2 8.12E-03     
cell cycle: g2/m checkpoint 24 19 3 1.01E-02 24 19 2 8.48E-02
Signaling events mediated by HDAC Class III 44 21 3 1.22E-02 44 21 2 8.62E-02
repression of pain sensation by the transcriptional regulator dream 15 8 2 1.38E-02     
mapkinase signaling pathway 41 39 4 1.40E-02 41 39 3 7.84E-02
rna polymerase iii transcription 10 8 2 1.47E-02     
Signaling events regulated by Ret tyrosine kinase 131 40 4 1.61E-02     
Signaling by Aurora kinases 162 59 5 1.76E-02     
IL2-mediated signaling events 184 64 6 1.87E-02 184 64 5 6.96E-02
Role of Calcineurin-dependent NFAT signaling in lymphocytes 133 64 5 1.88E-02     
oxidative stress induced gene expression via nrf2 16 10 2 2.15E-02     
G(s)-alpha mediated events in glucagon signalling 5 1 1 2.33E-02     
Activation of PUMA and translocation to mitochondria 1 1 1 2.41E-02     
Activation of NOXA and translocation to mitochondria 1 1 1 2.41E-02     
G2/M DNA damage checkpoint 7 1 1 2.41E-02     
Intrinsic Pathway for Apoptosis 32 12 2 3.05E-02     
agrin in postsynaptic differentiation 23 13 2 3.55E-02     
cadmium induces dna synthesis and proliferation in macrophages 37 13 2 3.55E-02     
Plasma membrane estrogen receptor signaling 547 217 11 3.66E-02 547 217 9 8.14E-02
il-2 receptor beta chain in t cell activation 42 31 3 3.77E-02     
hypoxia-inducible factor in the cardivascular system 26 14 2 4.08E-02     
BMP receptor signaling 329 163 9 4.33E-02 329 163 8 4.54E-02
Class I PI3K signaling events mediated by Akt 160 55 4 4.35E-02     
rho-selective guanine exchange factor akap13 mediates stress fiber formation 11 2 1 4.60E-02 11 2 1 4.64E-02
FasL/CD95L signaling 6 2 1 4.75E-02     
alk in cardiac myocytes 20 15 2 4.93E-02 20 15 3 6.12E-03
role of mef2d in t-cell apoptosis 31 15 2 5.22E-02 31 15 4 4.38E-04
TNF receptor signaling pathway 495 213 11 7.61E-02 495 213 11 3.77E-02
integrin signaling pathway 28 21 2 9.19E-02 28 21 3 1.42E-02
FAS signaling pathway (CD95)      63 26 5 2.99E-03
endocytotic role of ndk phosphins and dynamin      22 6 2 7.76E-03
BCR signaling pathway      94 52 5 8.63E-03
Integrins in angiogenesis      107 38 4 1.18E-02
Alkaloid biosynthesis II      45 21 3 1.81E-02
angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling      39 24 3 1.81E-02
t cell receptor signaling pathway      44 23 3 1.81E-02
links between pyk2 and map kinases      39 24 3 2.02E-02
dicer pathway      4 1 1 2.57E-02
AndrogenReceptor      98 93 6 3.29E-02
Osteopontin-mediated events      48 13 2 3.62E-02
TCR signaling in naïve CD8+ T cells      188 72 5 3.66E-02
fas signaling pathway (cd95)      24 14 2 4.16E-02
Ceramide signaling pathway      90 55 5 4.48E-02