Skip to main content
Figure 7 | Molecular Cancer

Figure 7

From: HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling

Figure 7

Model of HOXB13-mediated regulation of E2F signaling: Overexpression of HOXB13 in androgen-refractory prostate tumors inhibits the expression of the p21 waf tumor suppressor and subsequently activates cyclin dependent kinase 2 (CDK2) activities. Hyperphosphorylated RB releases E2F transcription factor, which drives the genes involved in cell proliferation, and results in increased cell survivability in the absence of hormone.

Back to article page

Molecular Cancer

ISSN: 1476-4598