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Figure 2 | Molecular Cancer

Figure 2

From: Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

Figure 2

FANCD2 and RAD51 nuclear focus formation to assess proximal and distal FA pathway function. (A) FANCD2 nuclear focus formation in RKO cells (positive control), derived RKO FANCG -/- cells (negative control), and a panel of five HCC cell lines including HuH-7, either treated with IR at 15 Gy for 6 h or left untreated. HuH-7 and RKO FANCG -/- cells lacked FANCD2 focus formation. (B) RAD51 nuclear focus formation in HuH-7 cells either treated with IR at 15 Gy for 6 h or left untreated.

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