Table 2 Gene ontology of common up-regulated genes. Only genes in the top-five ranking of each group are shown.
Gene ontology (%) | Accession no. | Description | Ratio |
|---|---|---|---|
Cellular metabolism (23.7%) | NM_000909 | neuropeptide Y receptor Y1 | 416.71 |
| Â | NM_004734 | doublecortin-like kinase 1 | 112.57 |
| Â | NM_002961 | S100 calcium binding protein A4 | 72.30 |
| Â | AF208502 | early B-cell factor 1 | 60.80 |
| Â | AW004016 | ST6 beta-galactosamide alpha-2,6 sialyltransferase 2 | 59.04 |
Protein binding (20.8%) | BF449063 | collagen, type XIV, alpha 1 (undulin) | 245.03 |
| Â | NM_002045 | growth associated protein 43 | 232.10 |
| Â | AI659533 | sorbin and SH3 domain containing 2 | 192.25 |
| Â | BF939176 | myozenin 2 | 139.5 |
| Â | AF333769 | contactin associated protein-like 3 | 106.75 |
Signal transduction (10.9%) | AW026543 | formyl peptide receptor-like 2 | 111.02 |
| Â | NM_004791 | integrin, beta-like 1 | 82.92 |
| Â | NM_005019 | phosphodiesterase 1A | 71.51 |
| Â | AF159570 | regulator of G-protein signalling 5 | 49.64 |
| Â | W67461 | angiopoietin-like 1 | 49.16 |
Extracellular region (7.8%) | NM_001086 | arylacetamide deacetylase (esterase) | 956.45 |
| Â | AI808090 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 669.24 |
| Â | NM_013363 | procollagen C-endopeptidase enhancer 2 | 224.83 |
| Â | AI889941 | collagen, type IV, alpha 6 | 77.06 |
| Â | NM_052866 | a disintegrin and metalloproteinase with thrombospondin motif-like 1 | 68.55 |
Transcription factor (7.5%) | AF332197 | sine oculis homeobox homolog 2 | 44.20 |
| Â | AI681917 | iroquois homeobox protein 3 | 35.34 |
| Â | NM_020639 | receptor-interacting serine-threonine kinase 4 | 29.41 |
| Â | AK023792 | PBX/knotted 1 homeobox 2 | 29.40 |
| Â | AF208967 | paternally expressed 3 | 26.74 |
Protein modification (5.5%) | AW975934 | Titin | 32.01 |
| Â | NM_020639 | receptor-interacting serine-threonine kinase 4 | 29.41 |
| Â | NM_000222 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 25.21 |
| Â | BF446673 | hemicentin 1 | 18.96 |
| Â | NM_002848 | protein tyrosine phosphatase, receptor type, O | 14.58 |
Receptor (4.8%) | BF941499 | G protein-coupled receptor 116 | 35.62 |
| Â | L35594 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 32.11 |
| Â | NM_002820 | parathyroid hormone-like hormone | 30.44 |
| Â | U61276 | jagged 1 (Alagille syndrome) | 19.60 |
| Â | AK022548 | integrin, alpha 7 | 15.62 |
Cell differentiation (4.3%) | AA343027 | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 67.06 |
| Â | NM_000216 | Kallmann syndrome 1 sequence | 27.91 |
| Â | AL560266 | Fc receptor-like A | 19.61 |
| Â | AA127691 | neuropilin 2 | 19.35 |
| Â | NM_002506 | nerve growth factor, beta polypeptide | 19.11 |
Cell adhesion (3.5%) | NM_006727 | cadherin 10, type 2 (T2-cadherin) | 55.43 |
| Â | NM_000072 | CD36 molecule (thrombospondin receptor) | 40.71 |
| Â | AL573851 | endothelial cell adhesion molecule | 22.52 |
| Â | N69091 | protocadherin 17 | 22.32 |
| Â | AA489646 | protocadherin beta 13 | 19.36 |
Cell cycle (2.4%) | NM_003914 | cyclin A1 | 34.8 |
| Â | NM_015714 | G0/G1switch 2 | 26.62 |
| Â | NM_001759 | cyclin D2 | 16.45 |
| Â | NM_001992 | coagulation factor II (thrombin) receptor | 13.90 |
| Â | AK024082 | Tousled-like kinase 2 | 11.09 |
Cell motility (2.2%) | NM_005045 | reelin | 17.30 |
| Â | NM_003062 | slit homolog 3 (Drosophila) | 5.12 |
| Â | M21121 | chemokine (C-C motif) ligand 5 | 5.06 |
| Â | NM_014795 | zinc finger E-box binding homeobox 2 | 4.85 |
| Â | D45864 | protein kinase, cGMP-dependent, type I | 4.74 |
Proteolysis (2.0%) | NM_001870 | carboxypeptidase A3 (mast cell) | 20.01 |
| Â | NM_024539 | ring finger protein 128 | 12.68 |
| Â | AL574912 | protease, serine, 35 | 11.59 |
| Â | NM_001873 | carboxypeptidase E | 9.45 |
| Â | NM_000892 | kallikrein B, plasma (Fletcher factor) 1 | 6.40 |
Cell proliferation (2.0%) | U77914 | jagged 1 (Alagille syndrome) | 16.76 |
| Â | NM_004624 | vasoactive intestinal peptide receptor 1 | 13.07 |
| Â | BF514079 | Kruppel-like factor 4 (gut) | 12.89 |
| Â | NM_001432 | epiregulin | 11.98 |
| Â | BC003355 | laminin, alpha 5 | 10.36 |
Apoptosis (1.6%) | NM_002575 | serpin peptidase inhibitor | 133.32 |
| Â | NM_000557 | growth differentiation factor 5 | 14.79 |
| Â | NM_003728 | unc-5 homolog C (C. elegans) | 9.60 |
| Â | BF432648 | tumor necrosis factor receptor superfamily | 8.73 |
| Â | NM_003551 | non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) | 6.80 |
ECM organization and biosynthesis (0.9%) | BC001186 | protocadherin beta 5 | 15.90 |
| Â | M25813 | tenascin XB | 12.46 |
| Â | NM_002380 | matrilin 2 | 4.89 |
| Â | AY140646 | periostin, osteoblast specific factor 2 | 4.89 |
| Â | NM_004612 | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa | 4.56 |