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Table 2 Gene ontology of common up-regulated genes. Only genes in the top-five ranking of each group are shown.

From: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

Gene ontology (%) Accession no. Description Ratio
Cellular metabolism (23.7%) NM_000909 neuropeptide Y receptor Y1 416.71
  NM_004734 doublecortin-like kinase 1 112.57
  NM_002961 S100 calcium binding protein A4 72.30
  AF208502 early B-cell factor 1 60.80
  AW004016 ST6 beta-galactosamide alpha-2,6 sialyltransferase 2 59.04
Protein binding (20.8%) BF449063 collagen, type XIV, alpha 1 (undulin) 245.03
  NM_002045 growth associated protein 43 232.10
  AI659533 sorbin and SH3 domain containing 2 192.25
  BF939176 myozenin 2 139.5
  AF333769 contactin associated protein-like 3 106.75
Signal transduction (10.9%) AW026543 formyl peptide receptor-like 2 111.02
  NM_004791 integrin, beta-like 1 82.92
  NM_005019 phosphodiesterase 1A 71.51
  AF159570 regulator of G-protein signalling 5 49.64
  W67461 angiopoietin-like 1 49.16
Extracellular region (7.8%) NM_001086 arylacetamide deacetylase (esterase) 956.45
  AI808090 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 669.24
  NM_013363 procollagen C-endopeptidase enhancer 2 224.83
  AI889941 collagen, type IV, alpha 6 77.06
  NM_052866 a disintegrin and metalloproteinase with thrombospondin motif-like 1 68.55
Transcription factor (7.5%) AF332197 sine oculis homeobox homolog 2 44.20
  AI681917 iroquois homeobox protein 3 35.34
  NM_020639 receptor-interacting serine-threonine kinase 4 29.41
  AK023792 PBX/knotted 1 homeobox 2 29.40
  AF208967 paternally expressed 3 26.74
Protein modification (5.5%) AW975934 Titin 32.01
  NM_020639 receptor-interacting serine-threonine kinase 4 29.41
  NM_000222 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 25.21
  BF446673 hemicentin 1 18.96
  NM_002848 protein tyrosine phosphatase, receptor type, O 14.58
Receptor (4.8%) BF941499 G protein-coupled receptor 116 35.62
  L35594 ectonucleotide pyrophosphatase/phosphodiesterase 2 32.11
  NM_002820 parathyroid hormone-like hormone 30.44
  U61276 jagged 1 (Alagille syndrome) 19.60
  AK022548 integrin, alpha 7 15.62
Cell differentiation (4.3%) AA343027 Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 67.06
  NM_000216 Kallmann syndrome 1 sequence 27.91
  AL560266 Fc receptor-like A 19.61
  AA127691 neuropilin 2 19.35
  NM_002506 nerve growth factor, beta polypeptide 19.11
Cell adhesion (3.5%) NM_006727 cadherin 10, type 2 (T2-cadherin) 55.43
  NM_000072 CD36 molecule (thrombospondin receptor) 40.71
  AL573851 endothelial cell adhesion molecule 22.52
  N69091 protocadherin 17 22.32
  AA489646 protocadherin beta 13 19.36
Cell cycle (2.4%) NM_003914 cyclin A1 34.8
  NM_015714 G0/G1switch 2 26.62
  NM_001759 cyclin D2 16.45
  NM_001992 coagulation factor II (thrombin) receptor 13.90
  AK024082 Tousled-like kinase 2 11.09
Cell motility (2.2%) NM_005045 reelin 17.30
  NM_003062 slit homolog 3 (Drosophila) 5.12
  M21121 chemokine (C-C motif) ligand 5 5.06
  NM_014795 zinc finger E-box binding homeobox 2 4.85
  D45864 protein kinase, cGMP-dependent, type I 4.74
Proteolysis (2.0%) NM_001870 carboxypeptidase A3 (mast cell) 20.01
  NM_024539 ring finger protein 128 12.68
  AL574912 protease, serine, 35 11.59
  NM_001873 carboxypeptidase E 9.45
  NM_000892 kallikrein B, plasma (Fletcher factor) 1 6.40
Cell proliferation (2.0%) U77914 jagged 1 (Alagille syndrome) 16.76
  NM_004624 vasoactive intestinal peptide receptor 1 13.07
  BF514079 Kruppel-like factor 4 (gut) 12.89
  NM_001432 epiregulin 11.98
  BC003355 laminin, alpha 5 10.36
Apoptosis (1.6%) NM_002575 serpin peptidase inhibitor 133.32
  NM_000557 growth differentiation factor 5 14.79
  NM_003728 unc-5 homolog C (C. elegans) 9.60
  BF432648 tumor necrosis factor receptor superfamily 8.73
  NM_003551 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) 6.80
ECM organization and biosynthesis (0.9%) BC001186 protocadherin beta 5 15.90
  M25813 tenascin XB 12.46
  NM_002380 matrilin 2 4.89
  AY140646 periostin, osteoblast specific factor 2 4.89
  NM_004612 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa 4.56