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Table 5 Multivariate analysis by Cox proportional hazard regression model for the evaluation of prognostic factors.

From: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

Variable

(No. of patients)

No. of dead

patients

Hazard ratio

95% confidence interval

P

 

(5-yr survival cut-off)

(HR)

(CI)

 

Age in years

    

≤ 57 (25)

21

1

  

>57 (26)

22

1.25

0.62-2.48

0.533

PN expression

    

Low (22)

17

1

  

High (29)

26

2.02

1.02-4.02

0.045*

Lymph node metastasis

    

Absence (36)

28

1

  

Presence (15)

15

3.13

1.54-6.35

0.002*

Histological type

    

Well-differentiated (20)

16

1

  

Moderately-differentiated (8)

8

2.77

1.10-6.98

0.031*

Poorly-differentiated (8)

7

1.64

0.63-4.29

0.310

Papillary (15)

12

0.60

0.25-1.44

0.254

Tumor size (cm)

    

≤ 5 (28)

23

1

  

>5 (23)

20

1.49

0.76-2.94

0.251

  1. * P value of equal or less than 0.05 means statistical significance