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Table 5 Multivariate analysis by Cox proportional hazard regression model for the evaluation of prognostic factors.

From: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

Variable
(No. of patients)
No. of dead
patients
Hazard ratio 95% confidence interval P
  (5-yr survival cut-off) (HR) (CI)  
Age in years     
≤ 57 (25) 21 1   
>57 (26) 22 1.25 0.62-2.48 0.533
PN expression     
Low (22) 17 1   
High (29) 26 2.02 1.02-4.02 0.045*
Lymph node metastasis     
Absence (36) 28 1   
Presence (15) 15 3.13 1.54-6.35 0.002*
Histological type     
Well-differentiated (20) 16 1   
Moderately-differentiated (8) 8 2.77 1.10-6.98 0.031*
Poorly-differentiated (8) 7 1.64 0.63-4.29 0.310
Papillary (15) 12 0.60 0.25-1.44 0.254
Tumor size (cm)     
≤ 5 (28) 23 1   
>5 (23) 20 1.49 0.76-2.94 0.251
  1. * P value of equal or less than 0.05 means statistical significance