From: Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives
Isotype
Substitutions at Binding Site
β III
X
Cys239-Ser
Ala315-Thr
Thr351-Val
β V
β VI
Val236-Ile
β VII
Val255-Met
Val313-Ala
β VIII