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Table 1 Tubulin Isotype Interactions with Colchicine

From: Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

Isotype

Substitutions at Binding Site

β III

X

Cys239-Ser

X

X

Ala315-Thr

Thr351-Val

β V

X

Cys239-Ser

X

X

Ala315-Thr

Thr351-Val

β VI

Val236-Ile

Cys239-Ser

X

X

Ala315-Thr

Thr351-Val

β VII

X

X

Val255-Met

Val313-Ala

X

X

β VIII

X

X

X

Val313-Ala

X

X