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Table 1 Tubulin Isotype Interactions with Colchicine

From: Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

Isotype Substitutions at Binding Site
β III X Cys239-Ser X X Ala315-Thr Thr351-Val
β V X Cys239-Ser X X Ala315-Thr Thr351-Val
β VI Val236-Ile Cys239-Ser X X Ala315-Thr Thr351-Val
β VII X X Val255-Met Val313-Ala X X
β VIII X X X Val313-Ala X X