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Table 4 The log IC50 values of colchicine and various colchicine derivatives

From: Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

  A549 HeLa MCF-7 CEM M010B M006X
D00 -6.46 ± 0.04 -6.86 ± 0.05 -7.83 ± 0.06 -8.03 ± 0.04 -7.70 ± 0.05 -8.35 ± 0.30
D01 -5.29 ± 0.11 N/A -5.25 ± 0.10 N/A N/A N/A
D02 -5.89 ± 0.06 -6.48 ± 0.13 -6.32 ± 0.11 -6.65 ± 0.08 N/A N/A
D03 -5.07 ± 0.04 -5.41 ± 0.13 -5.23 ± 0.07 -5.39 ± 0.11 N/A N/A
D04 -5.09 ± 0.06 -5.46 ± 0.13 -5.25 ± 0.08 -5.51 ± 0.13 -5.22 ± 0.07 -6.12 ± 0.04
D05 -7.83 ± 0.10 -7.89 ± 0.06 -7.42 ± 0.13 -8.64 ± 0.08 -7.94 ± 0.03 -8.41 ± 0.08
D06 -7.80 ± 0.07 -7.68 ± 0.09 -7.50 ± 0.13 -8.48 ± 0.09 -7.49 ± 0.13 -7.98 ± 0.03
D07 -7.66 ± 0.08 -8.25 ± 0.09 -8.10 ± 0.05 -8.49 ± 0.10 N/A N/A
D08 -6.52 ± 0.13 -6.66 ± 0.11 -6.17 ± 0.07 -6.76 ± 0.07 -6.60 ± 0.13 -7.12 ± 0.06
D09 -6.66 ± 0.09 -7.35 ± 0.09 -7.10 ± 0.04 -7.46 ± 0.08 -6.74 ± 0.08 -7.47 ± 0.09
D10 -6.47 ± 0.12 -7.23 ± 0.09 -7.05 ± 0.04 -7.45 ± 0.09 -6.74 ± 0.08 -7.40 ± 0.09
D11 -5.77 ± 0.10 -6.17 ± 0.07 -6.27 ± 0.08 -6.45 ± 0.08 -5.66 ± 0.10 -6.42 ± 0.09
D12 -4.51 ± 0.31 -5.33 ± 0.14 -5.19 ± 0.09 -5.50 ± 0.10 -4.90 ± 0.09 -5.67 ± 0.12
D13 -4.95 ± 0.07 -5.33 ± 0.11 -5.22 ± 0.08 -5.53 ± 0.11 -5.20 ± 0.08 -5.44 ± 0.13
D14 N/A N/A N/A N/A N/A N/A
D15 -6.00 ± 0.04 -6.43 ± 0.14 -6.30 ± 0.12 -6.46 ± 0.09 -6.39 ± 0.11 -6.47 ± 0.12
D16 -6.23 ± 0.08 -6.22 ± 0.09 -6.35 ± 0.12 -6.57 ± 0.11 -6.38 ± 0.14 -6.45 ± 0.13
D17 -7.38 ± 0.14 -7.77 ± 0.09 -7.37 ± 0.11 -8.47 ± 0.13 -7.65 ± 0.10 -8.34 ± 0.11
D18 -8.50 ± 0.12 -8.45 ± 0.11 -8.31 ± 0.13 -8.29 ± 0.10 N/A N/A
D19 -8.37 ± 0.11 -8.47 ± 0.14 -8.28 ± 0.10 -8.64 ± 0.09 -8.27 ± 0.12 -8.83 ± 0.08
D20 -8.76 ± 0.10 -8.66 ± 0.13 -8.71 ± 0.11 -8.55 ± 0.09 -8.51 ± 0.14 N/A
  1. The values are determined by cytotoxicity testing on six different cell lines. Each IC50 value represents the Effective Concentration at which the drug shows 50% of its efficacy on each particular cell line.