Figure 2From: Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumorsSPARC peptides FSEN and FSEC inhibit endothelial cell migration. HUVEC cells were treated with serial dilutions of SPARC peptides with or without 10 ng/ml bFGF in a modified Boyden chamber. Relative stimulation was calculated as percentage of bFGF-induced migration. (A) Peptide FSEN inhibited bFGF-stimulated endothelial migration with an EC50 of ~2 nM. (B) Peptide FSEC displayed a strong dose-dependent inhibition of bFGF-stimulated endothelial migration with an EC50 ~1 pM. Dark circles represent bFGF-stimulated migration; light circles represent basal migration in the absence of an activator.Back to article page