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Figure 3 | Molecular Cancer

Figure 3

From: Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid

Figure 3

The LPA3 receptor mediates viability in A375 and MeWo melanoma cells. Individual LPA receptors were targeted with siRNA to sequentially inhibit receptor expression. (A) A375 cells were transfected for 48 h with the indicated siRNA and examined for viability. *P < 0.05, vs. Mock in A375 by Bonferroni's t-test and analysis of variance. (B) RT-PCR showing LPA receptor expression in A375 cells visualized using the Bioanalyzer 2100. (C) MeWo cells were transfected for 48 h with the indicated siRNA and examined for viability. *P < 0.05, vs. Negative Control (RISC-free) in MeWo. (D) RT-PCR showing LPA receptor expression in MeWo cells visualized using the Bioanalyzer 2100. (E) RT-PCR showing LPA receptor expression in normal human skin visualized using the Bioanalyzer 2100.

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Molecular Cancer

ISSN: 1476-4598