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Figure 6 | Molecular Cancer

Figure 6

From: Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid

Figure 6

Thio-ccPA 18:1 reduces metastatic melanoma lesions in murine lungs. C57/BL6 mice (N = 27) were injected with 5 × 104 B16F10 cells into the tail vein. Thio-ccPA 18:1 was administered on days 3 and 7 during the 21-day study. (A) Necropsy images of left lung lobes demonstrate the presence of tumor. Quantification of tumor revealed a reduction in nodules on the lungs shown as both scatter (B) and bar (C) graphs. **p < 0.01 comparing control (PBS) with thio-ccPA 18:1 treated groups. (D) Quantification of additional lesions detected on organs outside the lungs (kidney, liver, pancreas and intestines) and presented as a percentage of mice in each group (Control N = 17, 100%; thio-ccPA 18:1 N = 2 of 10, 20%; thio-ccPA 18:1).

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Molecular Cancer

ISSN: 1476-4598