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Figure 1 | Molecular Cancer

Figure 1

From: Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy

Figure 1

Cx43 expression and functionality in glioblastoma and osteosarcoma cell lines. A. Immunofluorescence of Cx43 shown by confocal microscopy; scale bar: 20 μm: B. Intercellular communication measured by double dye flow cytometry. The percentage of communicating cells represents the percentage of DiI-stained cells that picked up calcein from calcein-loaded cells in presence (open bars) or not of AGA (red bars). Each value is the mean ± s.d. of triplicates of at least three separate experiments. Statistical significance between untreated and AGA-treated cells was evaluated by a Student t-test (*, p < 0.05; **, p < 0.01). Bystander effect of the thymidine kinase/ganciclovir strategy: C. In SKI-1 glioma cells. D. In MNNG/HOS osteosarcoma cells. Data are the means ± S.D. of five replicates of three separate experiments.

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