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Figure 1 | Molecular Cancer

Figure 1

From: The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability

Figure 1

Inhibition of androgen-independent DU145 (A) and PC3 (B) prostate cancer cell growth, migration and invasion by increasing doses of 4HPR is independent of ROS production (C). Cell proliferation, evaluated by the crystal violet assay, is significantly inhibited at all 4HPR concentrations tested after 96 h exposure (***P < 0.001). In migration and invasion assays, the conditioned medium from human fibroblasts (FB-CM) was used as chemoattractant in the lower chamber. Experiments were done in triplicate and repeated thrice. Means ± SD are shown (*P < 0.05, **P < 0.01, ***P < 0.001).

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Molecular Cancer

ISSN: 1476-4598