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Figure 2 | Molecular Cancer

Figure 2

From: Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival

Figure 2

Summary of genome-wide DNA copy number aberrations and concordant gene expression changes. A. Top panel: Percentage of genome DNA amplification (red) and deletion (green) of the 20 OSCC on the human autosomes. Only CNAs with tumor-normal DNA copy number ratio less than 0.7 or greater than 1.4 are counted as deleted or amplified, respectively. Bottom-panel: Manhattan plot of the negative base-10 log-transformed p-value for the correlation coefficients between DNA copy number and gene expression for all the studied genes at each loci. Line indicates the Bonferroni p-value cutoff = -log10(0.01/23,466) = 6.37; B. A close-up view of the 11q13.2-q13.3 high correlation region.

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