Figure 3

Heatmap and gene interaction networks of early HCC specific genes in young. (A) Venn diagram characterizing differential gene expression between and specific to different treatment types: early rat HCC (DY), regenerated (RY), and normal (NY). The number of HCC specific genes, 80, is circled in black. (B) Heatmap of HCC specific genes exclusively dysregulated (up/down regulated) in the HCC group only. (C-E) Top three scoring gene interaction networks (with highest relevance scores). Nodes represent genes, with their shape representing the functional class of the gene product, and edges indicate biological relationship between the nodes (see legend in Figure 2). (F) Top network functions associated with three networks shown. An IPA score of three indicates that there is 1/1000 (score = -log (p-value)) chance that the focus genes are assigned to a network randomly.