Table 2 Abnormally elevated proteins identified in PanIN3 juices by quantitative proteomics (by at least two-fold change)
gene symbol | protein description | ratio PanIN3 case a vs normal | PanIN3 case a SEM | ratio PanIN3 case b vs normal | PanIN3 case b SEM | ratio PanIN3 case c vs normal | PanIN3 case c SEM |
|---|---|---|---|---|---|---|---|
AGR2 | Anterior gradient-2 | 10.47 | 0.03 | 3.96 | 0.01 | 2.04 | 0.01 |
HIST1H2B | Histone H2B | 34.78 | 0.04 | 8.53 | 0.03 | 10.01 | 0.01 |
LYZ | Lysozyme C | 27.56 | 0.02 | 3.70 | 0.01 | 2.05 | 0.01 |
MUC5AC | Mucin-5AC | 31.06 | 0.01 | 3.83 | 0.00 | 4.54 | 0.00 |
CA2 | Carbonic anhydrase 2 | 9.58 | 0.02 | 3.18 | 0.01 | 1.97 | 0.01 |
KLK1 | Kallikrein-1 | 3.25 | 0.06 | 3.12 | 0.08 | 11.52 | 0.02 |
ANXA5 | Annexin A5 | 21.46 | 0.01 | 4.43 | 0.01 | 9.70 | 0.01 |
HIST2H4A | Histone H4 | 41.77 | 0.01 | 9.82 | 0.01 | 11.88 | 0.01 |
ANXA4 | Annexin A4 | 18.39 | 0.02 | 4.28 | 0.01 | 5.11 | 0.01 |
ACTB | Actin, cytoplasmic 1, 2 | 17.98 | 0.01 | 6.13 | 0.01 | 4.41 | 0.01 |
SERPINA1 | Alpha-1-antitrypsin | 11.03 | 0.04 | 4.30 | 0.02 | 1.99 | 0.02 |
KRT8 | Keratin, type II cytoskeletal 8 | 19.25 | 0.02 | 4.26 | 0.01 | 3.72 | 0.01 |
PRSS1 | PRSS1 protein | 4.56 | 0.01 | 15.35 | 0.02 | 30.46 | 0.03 |
YWHAE | 14-3-3 protein epsilon | 15.60 | 0.02 | 4.48 | 0.01 | 2.42 | 0.01 |
PPIA;LOC654188;PPIAL3 | Peptidyl-prolyl cis-trans isomerase A | 13.93 | 0.02 | 5.05 | 0.02 | 4.04 | 0.01 |
PSIP1 | PC4 and SFRS1-interacting protein | 2.68 | 0.01 | 17.91 | 0.00 | 12.16 | 0.01 |
AKR1B10 | Aldo-keto reductase family 1 member B10 | 14.60 | 0.01 | 8.32 | 0.01 | 5.01 | 0.00 |
CLIC1 | Chloride intracellular channel protein 1 | 5.84 | 0.04 | 3.22 | 0.04 | 4.08 | 0.04 |
C2 | Complement C2 | 4.94 | 0.01 | 24.53 | 0.02 | 17.69 | 0.03 |
HNRNPA2B1 | Heterogeneous nuclear ribonucleoproteins | 7.13 | 0.04 | 2.64 | 0.01 | 2.51 | 0.04 |