Figure 2From: Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signalingSuppression of tumorigenesis by re-introduction of wild-type FLCN not mutant FLCN in the FLCN -null cell line, UOK257. (A) Tumorigenesis of UOK257 cells in nude mice was suppressed by wild-type FLCN. Arrow indicates a tumor from UOK257-P cells. Arrowhead indicates a flat patch of tumor cells from UOK257-3 cells. (B) Histologies of the tumors from different clones of UOK257 cells. (a) high, (b) medium, and (c) low grade clear cell histologies; (d) papillary RCC.Back to article page