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Figure 4 | Molecular Cancer

Figure 4

From: The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

Figure 4

The modulation of E-cadherin, N-cadherin, and vimentin mRNA levels by WIF1 transfection is associated with its down-regulation of Slug, and Twist expression. A & B, quantitative real-time PCR analysis of E-cadherin, N-cadherin, vimentin, Slug, and Twist mRNA in the transfectants. Gene expression is presented as fold increase in Δ Ct compared with PCDNA3.1 vector control transfectants. Columns, mean of four independent quantitative real-time PCR experiments; Bars, ± SE. C, Western blot analysis of expression of Slug, Twist, and β-actin shown by a representative blot from three independent experiments.

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