Figure 2From: Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemiaCoBRA of ALL bone marrow DNA. A. Diagram of reverse-strand bisulfite-specific PCR fragment showing location of potential TaqαI restriction sites (T). B. TaqαI digests of TES bisulfite-specific PCR products from normal PBL, ALL and remission samples. Fully methylated DNA will generate fragments of 161, 109, 26, 39 and 42 bp respectively. (Marker lane; 100, 200, 300, 400 and 500 bp bands; U - undigested PCR product).Back to article page