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Table 1 Summary of leukaemia methylation and LOH status in ALL bone marrow aspirates

From: Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia

 

Bisulfite-specific data

Genomic DNA

 
 

Bisulfite (rev) SNPa

Biallelic Methylation

D7s655b

Genotype SNPc

LOHd

Notes

ALL1

  

2

C/T, C/T, C/T, A

N

Same as remission

ALL2

GAG

 

2

C, T, C, A

N

 

ALL3

GAG, AAG

Y

1

C, T, C/T, A

N

Same as remission

ALL4

  

1

C/T, C/T, C/T, A

N

 

ALL5

  

1

C, T, C/T, A

N

 

ALL6

  

2

 

N

 

ALL7

  

2

 

N

 

ALL8

GAG, AAG

Y

1

 

N

 

ALL9

GGA, AAG

Y

  

N

 

ALL10

GAG, GGA

Y

  

N

 

ALL11

  

2

 

N

 

ALL12

GAG

 

2

 

N

 

ALL13

     

LOH?

ALL14

  

2

 

N

 

ALL15

  

1

 

Non-Informative

 

ALL16

AAG

    

LOH?

ALL17

    

Non-Informative

LOH?

ALL18

GGA, GAG

Y

1

C/T, C/T, C, A

N

Same as remission

ALL19

GGA

   

Non-Informative

Same as remission

ALL20

GGA

 

1

 

Non-Informative

LOH?

  1. a SNP data (rs1319886, rs2811392, rs11549785) generated from bisulfite sequencing. bNumber of alleles at D7s655 microsatellite. cSNP data (rs11549786, rs11549785, rs2811392, rs1319886) generated from promoter sequencing. d Summary of loss of heterozygosity status.