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Figure 5 | Molecular Cancer

Figure 5

From: CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

Figure 5

Effect of hypoxia and CXCR4 inhibition on the invasion of chondrosarcoma cells. JJ cells were cultured under normoxia or in hypoxia with 10 ng/ml SDF1 in the presence or absence of 0.1 μM of AMD3100 for 48 h (AMD3100 was added 2 h before SDF1) before performing the invasion assay, which was also performed during normoxia or hypoxia with or without AMD3100. *, p < 0.01; #, p < 0.05 compared to Hypoxia. Upper panel, bar graphs represent data from three independent experiments. Lower panel, representative photographs of stained cells on the lower side of matrigel membrane from one of three experiments. Original magnifications, 100×.

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Molecular Cancer

ISSN: 1476-4598