Figure 1From: Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancersObserved RB1 mutations. (a) Schematic representation of the pRb protein. (b) We observed three novel point mutations in RB1: The C1819A mutation (Leu607Ile), the C1861T mutation (Arg621Cys), and the A2092T mutation (Arg698Trp), all leading to amino acid substitutions inside the pRb pocket domain.Back to article page