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Figure 3 | Molecular Cancer

Figure 3

From: Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers

Figure 3

Multiple sequence alignment of the pRb spacer region. A multiple sequence alignment of the spacer region between the A and B boxes of the pRb pocket was generated with ClustalX using default parameters [24]. The locations of two of the mutations reported here are marked with black arrows, and two previously reported mutations are shown in grey [32, 33]. Sequences from eight different species were included in the alignment: Human [UNIPROT: P06400 RB_HUMAN], cow [UNIPROT: Q08E68_BOVIN], mouse [UNIPROT: P13405 RB_MOUSE], chicken [UNIPROT: Q90600 RB_CHICK], newt [UNIPROT: Q98966_NOTVI], salmon [UNIPROT: C0H9R0_SALSA], killifish [UNIPROT: Q5J3Q9_FUNHE], and zebrafish [UNIPROT: A0JMQ4_DANRE].

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Molecular Cancer

ISSN: 1476-4598