Schematic summary of regulatory network controlling TLX1/NOTCH signature genes. NOTCH1 activates transcription of downstream transcriptional regulators MYC and HES. TLX1 augments MYC protein levels. HES represses transcription via interaction with TLE [41–43]. TLX1 interacts with TLE to mediate repression and activation of transcription . MYC binds TLE directly in vitro . However, it is not known whether TLE is required for MYC repressor activity (indicated by "?"). We speculate that the genes coregulated by the TLX1/TLE/NOTCH/MYC network are critical for TLX1/NOTCH transforming function in T-ALL.