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Table 1 TLX1/NOTCH signature gene response to MYC inhibition in ALL-SIL cells

From: TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells

Gene

Fold Downregulation

CD1B

3.6 ± 0.4

HMGA2

2.4 ± 0.3

L1TD1

5.9 ± 0.4

OR10R2

1.9 ± 0.1

PLAC8

0.5 ± 0.1

RAG1

11.1 ± 2.7

SH3BP5

1.2 ± 0.1

SLC44A1

1.5 ± 0.1

  1. Fold downregulation was defined as the ratio of the qRT-PCR values obtained for untreated cells (DMSO) versus cells treated for 2 days with 50 μM of the MYC inhibitor 10058-F4.
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Molecular Cancer

ISSN: 1476-4598