Figure 10
From: NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells
BA increases and parthenolide decreases expression of NF-κB target genes. RT-qPCR analysis showing that BA (B; 10 μM) increases expression of IκBα (top left), DR5 (top right), and A20 (bottom left) mRNAs in combination with 2ME2 (M; 5 μM) or Doc (D; 1 nM) (MB, DB) in LNCaP cells (48 h). Parthenolide (P; 10 μM) decreases the M and D increase in A20 (MP, DP) in LNCaP cells (72 h) (lower right panel). mRNA levels are normalized to control (C) = 1. n = 5, three independent experiments. *, P < 0.05.