TY - JOUR AU - Liu, Ying AU - Chen, Yanfeng AU - Momin, Amin AU - Shaner, Rebecca AU - Wang, Elaine AU - Bowen, Nathan J. AU - Matyunina, Lilya V. AU - Walker, L. DeEtte AU - McDonald, John F. AU - Sullards, M. Cameron AU - Merrill, Alfred H. PY - 2010 DA - 2010/07/12 TI - Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry JO - Molecular Cancer SP - 186 VL - 9 IS - 1 AB - Sulfatides (ST) are a category of sulfated galactosylceramides (GalCer) that are elevated in many types of cancer including, possibly, ovarian cancer. Previous evidence for elevation of ST in ovarian cancer was based on a colorimetric reagent that does not provide structural details and can also react with other lipids. Therefore, this study utilized mass spectrometry for a structure-specific and quantitative analysis of the types, amounts, and tissue localization of ST in ovarian cancer, and combined these findings with analysis of mRNAs for the relevant enzymes of ST metabolism to explore possible mechanisms. SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-9-186 DO - 10.1186/1476-4598-9-186 ID - Liu2010 ER -