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Figure 6 | Molecular Cancer

Figure 6

From: SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies

Figure 6

Gene Chip analysis reveal SOX11-induced regulation of Rb-E2F and TGF-β signaling pathways. Ingenuity Pathway Analysis identified the canonical pathway "Molecular Mechanisms in Cancer" as highly associated with the 3647 deregulated genes. Within this pathway RB-E2F (A and B) and TGF-β (C and D) signaling is regulated in a time-dependent manner as shown after 24 h (A and C) and 48 h (B and D) of ectopic SOX11-overexpression. The differentially regulated genes are marked in red or green when the mean fold change for GRANTA-519 and JEKO-1 was ≥1.2 or ≤1.2. The remaining differentially regulated genes, including genes with different kinetics in the two cell lines, are marked in grey.

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Molecular Cancer

ISSN: 1476-4598