Figure 5From: Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expressionStructure of the N-terminal exons of EML4. The coiled-coil domain (CC) is responsible for dimerization and constitutive activation of EML4-ALK; HELP, hydrophobic EMAP-like protein domain; WD, WD-repeat domain.Back to article page