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Table 1 Changes in transcript expression in PTEN null and WT mice following SF-rich diets (LSF, HSF) and control diet (CO).

From: The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

Comparison

Five weeks

Eight weeks

 

p < 0.11

p < 0.051

p < 0.011

p < 0.11

p < 0.051

p < 0.011

WT

      

LSF vs CO

0

0

0

3

3

0

HSF vs CO

3

0

0

0

0

0

PTEN null

      

LSF vs CO

17

3

0

26

12

1

HSF vs CO

2862

803

11

189

72

25

Interaction

      

PTEN null CO vs WT CO

385

1984

8

1542

9895

296

PTEN null LSF vs WT CO

660

287

42

2379

17185

822

PTEN null HSF vs WT CO

15

0

0

3380

23905

1204

  1. 1 Benjamini and Hochberg adjusted P-values between the two groups.
  2. 2 Further details of these transcripts are provided in Figure 8 and Table 2.
  3. 3Human orthologues of these transcripts were identified and compared to results from a human dietary intervention study performed previously (Figure 9).
  4. 4Details of these transcripts and their expression are provided in Figure 10A and Additional file 1 - Table S1.
  5. 5Functional analyses of these transcripts are provided in Table 3, and further analyses in Figure 11.