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Figure 1 | Molecular Cancer

Figure 1

From: New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Figure 1

Histopathological, immunohistochemical and FACS analyses of the mice tumor xenografts. Tumors recovered from the control (vehicle treated; A-D) and SB-T-1214 treated (E-G) mice were sectioned and stained with hematoxylin and eosin (A, E), human epithelial adhesion molecule h EpCAM-FITC; B, F) and CD133-FITC (C, G). The tissue section from vehicle treated mouse show large area of living tumor positive for human EpCAM-FITC (B). Cluster of the CD133-positive cells from the outer tumor area (C). FACS analysis of the dissociated and immunomagnetically sorted for hEpCAM untreated mice tumor xenograft shows the presence of the minor population of cancer cells with high combined expression of CD133-APC and CD44-PE (dashed square; D). Complete loss of the tumor cells (E) and h EpCAM- (F) and CD133-positivity (G) after three consequents treatments with SB-T-1214.

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Molecular Cancer

ISSN: 1476-4598