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Figure 5 | Molecular Cancer

Figure 5

From: New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Figure 5

Drug-induced alteration in the stem cell-related gene expression profiles (PCR Array assay). A majority of the stemness genes were up-regulated in floating spheroids grown from CD133high/CD44high cells derived from HCT116, HT29 and DLD-1 cell lines in comparison with their corresponding bulk counterparts (left panel). Treatment of colonospheres with 100 nM SB-T-1214 induced significant down-regulation of a majority of the stemness genes (treated colonospheres were analyzed compared to untreated ones).

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