Figure 6From: New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cellsDrug-induced alterations in the expression of the markers of pluripotency. FACS analysis shows the presence of minor subpopulations of colon cancer cells within the 3D spheroids induced by CD133high/CD44high cells (A), which express the three key pluripotency genes (Sox2, Oct4, and c-Myc). Western blot analysis shows the SB-T-1214-induced changes in the levels of protein expression of these pluripotency markers (B). Untreated spheroids (Con 1 and Cont 2); treated with drug (SB 1 and SB 2).Back to article page