New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Table 1 Antitumor effect of SBT-1214 delivered i.v. to SCID mice bearing PgP+ DLD-1 human colon tumor xenografts.

Treatment^a	Sche-dule	Total Dose (mg/kg)	Dose/inj (mg/kg)	Days to 600 mm³	P value^b(Control)	Growth Delay (days)	Toxicity^c	Cured Mice per group^d
Control		0	0	17	---	---	0	0/10
Vehicle-tween Paclitaxel	q3d × 3 q3d × 3	0 60	0 20	16	.405 <.001	-1 8	0 0	0/4 0/5
SB-1214	q3d × 3	30	10	54	<.001	37	0	0/5
SB-1214	q3d × 3	60	20	>201	<.001	>150	0	5/5
SB-1214	q3d × 3	120	40	>201	.001	>150	2	3/5

^aTreatment given IV to SCID mice on day 5 after DLD-1 human colon tumor implant, and continued as noted; all drugs formulated in Tween/EtOH
^bBased on comparison of each group vs. control using the Cox-Mantel Test
^cNumber of animals who either died or lost greater than 20% body weight
^dSCID mice with no palpable tumor at end of experiment day 167.

ISSN: 1476-4598