Figure 1

Histological analysis of tumors arising in Trp53^ΔEC and Rb^ΔEC; Trp53^ΔEC mice. Histology sections showing (a) a representative example of subcutaneous tumor mass arising from the hair follicle in a Rb^ΔEC; Trp53^ΔEC mouse, (b) a poorly differentiated SCC from a Rb^ΔEC; Trp53^ΔEC mouse, (c) a highly undifferentiated tumor from a Trp53^ΔEC mouse, and (d) a spindle cell carcinoma in a Rb^ΔEC; Trp53^ΔEC mouse. (e) Proportion of tumors arising in both mouse models. Advanced stage tumors were classified histopathologically into poorly differentiated, undifferentiated and spindle cell carcinomas.