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Table 2 Mouse and human tumor signatures

From: Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

Gene Symbol Gene Title Gene Function
Mouse and human tumor signature associated with TP53 mutation1: 51-gene signature
ACTL6A actin-like 6A chromatin remodeling, histone H4 and H2A acetylation
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) chromatin assembly or disassembly, regulation of transcription
AURKA aurora kinase A mitotic cell cycle, spindle organization
BIRC5 baculoviral IAP repeat-containing 5 microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint
BLM Bloom syndrome, RecQ helicase-like telomere maintenance, G2/M transition DNA damage checkpoint
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) mitotic cell cycle spindle assembly checkpoint
C21orf45 chromosome 21 open reading frame 45 mitosis
CCNA2 cyclin A2 mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus
CDC2 cell division cycle 2, G1 to S and G2 to M APC-dependent proteasomal ubiquitin-dependent protein catabolic process
CDC20 cell division cycle 20 homolog (S. cerevisiae) APC-dependent proteasomal ubiquitin-dependent protein catabolic process
CDC45L CDC45 cell division cycle 45-like (S. cerevisiae) DNA replication checkpoint, DNA replication initiation
CDC6 cell division cycle 6 homolog (S. cerevisiae) DNA replication checkpoint, traversing start control point of mitotic cell cycle
CDC7 cell division cycle 7 homolog (S. cerevisiae) G1/S transition of mitotic cell cycle, DNA replication
CDCA3 cell division cycle associated 3 mitosis
CDCA8 cell division cycle associated 8 mitotic metaphase, chromosome organization
CDKN3 cyclin-dependent kinase inhibitor 3 regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle
CDT1 chromatin licensing and DNA replication factor 1 DNA replication checkpoint, regulation of DNA replication initiation
CENPA centromere protein A establishment of mitotic spindle orientation, nucleosome assembly
CENPE centromere protein E, 312kDa mitotic chromosome movement towards spindle pole, mitotic metaphase plate congression, kinetochore assembly
CEP55 centrosomal protein 55kDa mitosis
CHEK1 CHK1 checkpoint homolog (S. pombe) DNA damage checkpoint, G2/M transition of mitotic cell cycle
CKS2 CDC28 protein kinase regulatory subunit 2 regulation of cyclin-dependent protein kinase activity, spindle organization
CTPS CTP synthase CTP biosynthetic process, response to drug
DEPDC1 DEP domain containing 1 intracellular signaling cascade, GTPase activator activity
FEN1 flap structure-specific endonuclease 1 DNA repair, UV protection
FOXM1 forkhead box M1 regulation of transcription, DNA-dependent
GMPS guanine monphosphate synthetase GMP biosynthetic process
HMMR hyaluronan-mediated motility receptor (RHAMM) receptor activity, hyaluronic acid binding
KIF2C kinesin family member 2C establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation
KIF4A kinesin family member 4A microtubule-based movement, anterograde axon cargo transport
KIFC1 kinesin family member C1 mitotic sister chromatid segregation, microtubule-based movement
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process
MCM2 minichromosome maintenance complex component 2 DNA replication initiation, regulation of transcription
MCM3 minichromosome maintenance complex component 3 DNA replication initiation, regulation of transcription
MCM4 minichromosome maintenance complex component 4 DNA replication initiation, regulation of transcription
MCM5 minichromosome maintenance complex component 5 DNA replication initiation, regulation of transcription
MCM7 minichromosome maintenance complex component 7 DNA replication initiation, regulation of transcription, response to DNA damage stimulus
MLF1IP MLF1 interacting protein regulation of transcription, DNA-dependent
NCAPH non-SMC condensin I complex, subunit H mitotic chromosome condensation
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) establishment of mitotic spindle orientation, attachment of spindle microtubules to kinetochore
PLK1 polo-like kinase 1 (Drosophila) mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
PLSCR1 phospholipid scramblase 1 phospholipid scrambling, platelet activation
PRC1 protein regulator of cytokinesis 1 mitotic spindle elongation, cytokinesis
RAD54L RAD54-like (S. cerevisiae) double-strand break repair via homologous recombination, response to ionizing radiation
TFDP2 Transcription factor Dp-2 (E2F dimerization partner 2) regulation of transcription, DNA-dependent; cell cycle
TMEM48 transmembrane protein 48 protein and mRNA transport, nuclear pore complex assembly
TOP2A Topoisomerase (DNA) II alpha 170kDa DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis
TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis) mitosis
TRIP13 thyroid hormone receptor interactor 13 double-strand break repair, transcription from RNA polymerase II promoter
UBE2C ubiquitin-conjugating enzyme E2C spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process
Mouse and human tumor signature associated with poor prognosis2: 26-gene sinature
AURKA* aurora kinase A mitotic cell cycle, spindle organization
AURKB aurora kinase B mitosis, protein localization to kinetochore
BIRC5* baculoviral IAP repeat-containing 5 microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint
BUB1* budding uninhibited by benzimidazoles 1 homolog (yeast) mitotic cell cycle spindle assembly checkpoint
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) apoptosis, mitotic cell cycle checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process
CCNA2* cyclin A2 mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus
CDC2* Cell division cycle 2, G1 to S and G2 to M APC-dependent proteasomal ubiquitin-dependent protein catabolic process
CDC20* cell division cycle 20 homolog (S. cerevisiae) APC-dependent proteasomal ubiquitin-dependent protein catabolic process
CDKN3* cyclin-dependent kinase inhibitor 3 regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle
CENPA* centromere protein A establishment of mitotic spindle orientation, nucleosome assembly
CHEK1* CHK1 checkpoint homolog (S. pombe) DNA damage checkpoint, G2/M transition of mitotic cell cycle
CKS1B CDC28 protein kinase regulatory subunit 1B regulation of cyclin-dependent protein kinase activity
CKS2* CDC28 protein kinase regulatory subunit 2 regulation of cyclin-dependent protein kinase activity, spindle organization
H2AFZ H2A histone family, member Z nucleosome assembly
HMMR* hyaluronan-mediated motility receptor (RHAMM) receptor activity, hyaluronic acid binding
KIF11 kinesin family member 11 mitotic centrosome separation, spindle pole body organization
KIF2C* kinesin family member 2C establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation
KPNA2* karyopherin alpha 2 (RAG cohort 1, importin alpha 1) regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus
MAD2L1* MAD2 mitotic arrest deficient-like 1 (yeast) mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process
MCM4* minichromosome maintenance complex component 4 DNA replication initiation, regulation of transcription
NCAPH* non-SMC condensin I complex, subunit H mitotic chromosome condensation
PLK1* polo-like kinase 1 (Drosophila) mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
PLK4 polo-like kinase 4 (Drosophila) positive regulation of centriole replication
TOP2A* Topoisomerase (DNA) II alpha 170kDa DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis
TPX2* TPX2, microtubule-associated, homolog (Xenopus laevis) mitosis
UBE2C* ubiquitin-conjugating enzyme E2C spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process
  1. 1Genes were selected if they have a significant differential expression between wild type and TP53-mutated human tumors, in at list 5 out of 10 human studies (Fig. 4a)
  2. 2Genes were selected if they have a significant differential expression between primary tumors with poor versus good outcome in at list 14 out of 28 human studies (Fig. 4c)
  3. *Genes common between both lists: 20-gene signature