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Table 2 Mouse and human tumor signatures

From: Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

Gene Symbol

Gene Title

Gene Function

Mouse and human tumor signature associated with TP53 mutation1: 51-gene signature

ACTL6A

actin-like 6A

chromatin remodeling, histone H4 and H2A acetylation

ASF1B

ASF1 anti-silencing function 1 homolog B (S. cerevisiae)

chromatin assembly or disassembly, regulation of transcription

AURKA

aurora kinase A

mitotic cell cycle, spindle organization

BIRC5

baculoviral IAP repeat-containing 5

microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint

BLM

Bloom syndrome, RecQ helicase-like

telomere maintenance, G2/M transition DNA damage checkpoint

BUB1

budding uninhibited by benzimidazoles 1 homolog (yeast)

mitotic cell cycle spindle assembly checkpoint

C21orf45

chromosome 21 open reading frame 45

mitosis

CCNA2

cyclin A2

mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus

CDC2

cell division cycle 2, G1 to S and G2 to M

APC-dependent proteasomal ubiquitin-dependent protein catabolic process

CDC20

cell division cycle 20 homolog (S. cerevisiae)

APC-dependent proteasomal ubiquitin-dependent protein catabolic process

CDC45L

CDC45 cell division cycle 45-like (S. cerevisiae)

DNA replication checkpoint, DNA replication initiation

CDC6

cell division cycle 6 homolog (S. cerevisiae)

DNA replication checkpoint, traversing start control point of mitotic cell cycle

CDC7

cell division cycle 7 homolog (S. cerevisiae)

G1/S transition of mitotic cell cycle, DNA replication

CDCA3

cell division cycle associated 3

mitosis

CDCA8

cell division cycle associated 8

mitotic metaphase, chromosome organization

CDKN3

cyclin-dependent kinase inhibitor 3

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle

CDT1

chromatin licensing and DNA replication factor 1

DNA replication checkpoint, regulation of DNA replication initiation

CENPA

centromere protein A

establishment of mitotic spindle orientation, nucleosome assembly

CENPE

centromere protein E, 312kDa

mitotic chromosome movement towards spindle pole, mitotic metaphase plate congression, kinetochore assembly

CEP55

centrosomal protein 55kDa

mitosis

CHEK1

CHK1 checkpoint homolog (S. pombe)

DNA damage checkpoint, G2/M transition of mitotic cell cycle

CKS2

CDC28 protein kinase regulatory subunit 2

regulation of cyclin-dependent protein kinase activity, spindle organization

CTPS

CTP synthase

CTP biosynthetic process, response to drug

DEPDC1

DEP domain containing 1

intracellular signaling cascade, GTPase activator activity

FEN1

flap structure-specific endonuclease 1

DNA repair, UV protection

FOXM1

forkhead box M1

regulation of transcription, DNA-dependent

GMPS

guanine monphosphate synthetase

GMP biosynthetic process

HMMR

hyaluronan-mediated motility receptor (RHAMM)

receptor activity, hyaluronic acid binding

KIF2C

kinesin family member 2C

establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation

KIF4A

kinesin family member 4A

microtubule-based movement, anterograde axon cargo transport

KIFC1

kinesin family member C1

mitotic sister chromatid segregation, microtubule-based movement

KPNA2

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus

MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process

MCM2

minichromosome maintenance complex component 2

DNA replication initiation, regulation of transcription

MCM3

minichromosome maintenance complex component 3

DNA replication initiation, regulation of transcription

MCM4

minichromosome maintenance complex component 4

DNA replication initiation, regulation of transcription

MCM5

minichromosome maintenance complex component 5

DNA replication initiation, regulation of transcription

MCM7

minichromosome maintenance complex component 7

DNA replication initiation, regulation of transcription, response to DNA damage stimulus

MLF1IP

MLF1 interacting protein

regulation of transcription, DNA-dependent

NCAPH

non-SMC condensin I complex, subunit H

mitotic chromosome condensation

NDC80

NDC80 homolog, kinetochore complex component (S. cerevisiae)

establishment of mitotic spindle orientation, attachment of spindle microtubules to kinetochore

PLK1

polo-like kinase 1 (Drosophila)

mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

PLSCR1

phospholipid scramblase 1

phospholipid scrambling, platelet activation

PRC1

protein regulator of cytokinesis 1

mitotic spindle elongation, cytokinesis

RAD54L

RAD54-like (S. cerevisiae)

double-strand break repair via homologous recombination, response to ionizing radiation

TFDP2

Transcription factor Dp-2 (E2F dimerization partner 2)

regulation of transcription, DNA-dependent; cell cycle

TMEM48

transmembrane protein 48

protein and mRNA transport, nuclear pore complex assembly

TOP2A

Topoisomerase (DNA) II alpha 170kDa

DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis

TPX2

TPX2, microtubule-associated, homolog (Xenopus laevis)

mitosis

TRIP13

thyroid hormone receptor interactor 13

double-strand break repair, transcription from RNA polymerase II promoter

UBE2C

ubiquitin-conjugating enzyme E2C

spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process

Mouse and human tumor signature associated with poor prognosis2: 26-gene sinature

AURKA*

aurora kinase A

mitotic cell cycle, spindle organization

AURKB

aurora kinase B

mitosis, protein localization to kinetochore

BIRC5*

baculoviral IAP repeat-containing 5

microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint

BUB1*

budding uninhibited by benzimidazoles 1 homolog (yeast)

mitotic cell cycle spindle assembly checkpoint

BUB1B

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

apoptosis, mitotic cell cycle checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process

CCNA2*

cyclin A2

mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus

CDC2*

Cell division cycle 2, G1 to S and G2 to M

APC-dependent proteasomal ubiquitin-dependent protein catabolic process

CDC20*

cell division cycle 20 homolog (S. cerevisiae)

APC-dependent proteasomal ubiquitin-dependent protein catabolic process

CDKN3*

cyclin-dependent kinase inhibitor 3

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle

CENPA*

centromere protein A

establishment of mitotic spindle orientation, nucleosome assembly

CHEK1*

CHK1 checkpoint homolog (S. pombe)

DNA damage checkpoint, G2/M transition of mitotic cell cycle

CKS1B

CDC28 protein kinase regulatory subunit 1B

regulation of cyclin-dependent protein kinase activity

CKS2*

CDC28 protein kinase regulatory subunit 2

regulation of cyclin-dependent protein kinase activity, spindle organization

H2AFZ

H2A histone family, member Z

nucleosome assembly

HMMR*

hyaluronan-mediated motility receptor (RHAMM)

receptor activity, hyaluronic acid binding

KIF11

kinesin family member 11

mitotic centrosome separation, spindle pole body organization

KIF2C*

kinesin family member 2C

establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation

KPNA2*

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus

MAD2L1*

MAD2 mitotic arrest deficient-like 1 (yeast)

mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process

MCM4*

minichromosome maintenance complex component 4

DNA replication initiation, regulation of transcription

NCAPH*

non-SMC condensin I complex, subunit H

mitotic chromosome condensation

PLK1*

polo-like kinase 1 (Drosophila)

mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

PLK4

polo-like kinase 4 (Drosophila)

positive regulation of centriole replication

TOP2A*

Topoisomerase (DNA) II alpha 170kDa

DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis

TPX2*

TPX2, microtubule-associated, homolog (Xenopus laevis)

mitosis

UBE2C*

ubiquitin-conjugating enzyme E2C

spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process

  1. 1Genes were selected if they have a significant differential expression between wild type and TP53-mutated human tumors, in at list 5 out of 10 human studies (Fig. 4a)
  2. 2Genes were selected if they have a significant differential expression between primary tumors with poor versus good outcome in at list 14 out of 28 human studies (Fig. 4c)
  3. *Genes common between both lists: 20-gene signature