Gene Symbol | Gene Title | Gene Function |
---|---|---|
Mouse and human tumor signature associated with TP53 mutation1: 51-gene signature | ||
ACTL6A | actin-like 6A | chromatin remodeling, histone H4 and H2A acetylation |
ASF1B | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | chromatin assembly or disassembly, regulation of transcription |
AURKA | aurora kinase A | mitotic cell cycle, spindle organization |
BIRC5 | baculoviral IAP repeat-containing 5 | microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint |
BLM | Bloom syndrome, RecQ helicase-like | telomere maintenance, G2/M transition DNA damage checkpoint |
BUB1 | budding uninhibited by benzimidazoles 1 homolog (yeast) | mitotic cell cycle spindle assembly checkpoint |
C21orf45 | chromosome 21 open reading frame 45 | mitosis |
CCNA2 | cyclin A2 | mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus |
CDC2 | cell division cycle 2, G1 to S and G2 to M | APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
CDC20 | cell division cycle 20 homolog (S. cerevisiae) | APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
CDC45L | CDC45 cell division cycle 45-like (S. cerevisiae) | DNA replication checkpoint, DNA replication initiation |
CDC6 | cell division cycle 6 homolog (S. cerevisiae) | DNA replication checkpoint, traversing start control point of mitotic cell cycle |
CDC7 | cell division cycle 7 homolog (S. cerevisiae) | G1/S transition of mitotic cell cycle, DNA replication |
CDCA3 | cell division cycle associated 3 | mitosis |
CDCA8 | cell division cycle associated 8 | mitotic metaphase, chromosome organization |
CDKN3 | cyclin-dependent kinase inhibitor 3 | regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle |
CDT1 | chromatin licensing and DNA replication factor 1 | DNA replication checkpoint, regulation of DNA replication initiation |
CENPA | centromere protein A | establishment of mitotic spindle orientation, nucleosome assembly |
CENPE | centromere protein E, 312kDa | mitotic chromosome movement towards spindle pole, mitotic metaphase plate congression, kinetochore assembly |
CEP55 | centrosomal protein 55kDa | mitosis |
CHEK1 | CHK1 checkpoint homolog (S. pombe) | DNA damage checkpoint, G2/M transition of mitotic cell cycle |
CKS2 | CDC28 protein kinase regulatory subunit 2 | regulation of cyclin-dependent protein kinase activity, spindle organization |
CTPS | CTP synthase | CTP biosynthetic process, response to drug |
DEPDC1 | DEP domain containing 1 | intracellular signaling cascade, GTPase activator activity |
FEN1 | flap structure-specific endonuclease 1 | DNA repair, UV protection |
FOXM1 | forkhead box M1 | regulation of transcription, DNA-dependent |
GMPS | guanine monphosphate synthetase | GMP biosynthetic process |
HMMR | hyaluronan-mediated motility receptor (RHAMM) | receptor activity, hyaluronic acid binding |
KIF2C | kinesin family member 2C | establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation |
KIF4A | kinesin family member 4A | microtubule-based movement, anterograde axon cargo transport |
KIFC1 | kinesin family member C1 | mitotic sister chromatid segregation, microtubule-based movement |
KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus |
MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
MCM2 | minichromosome maintenance complex component 2 | DNA replication initiation, regulation of transcription |
MCM3 | minichromosome maintenance complex component 3 | DNA replication initiation, regulation of transcription |
MCM4 | minichromosome maintenance complex component 4 | DNA replication initiation, regulation of transcription |
MCM5 | minichromosome maintenance complex component 5 | DNA replication initiation, regulation of transcription |
MCM7 | minichromosome maintenance complex component 7 | DNA replication initiation, regulation of transcription, response to DNA damage stimulus |
MLF1IP | MLF1 interacting protein | regulation of transcription, DNA-dependent |
NCAPH | non-SMC condensin I complex, subunit H | mitotic chromosome condensation |
NDC80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | establishment of mitotic spindle orientation, attachment of spindle microtubules to kinetochore |
PLK1 | polo-like kinase 1 (Drosophila) | mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle |
PLSCR1 | phospholipid scramblase 1 | phospholipid scrambling, platelet activation |
PRC1 | protein regulator of cytokinesis 1 | mitotic spindle elongation, cytokinesis |
RAD54L | RAD54-like (S. cerevisiae) | double-strand break repair via homologous recombination, response to ionizing radiation |
TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | regulation of transcription, DNA-dependent; cell cycle |
TMEM48 | transmembrane protein 48 | protein and mRNA transport, nuclear pore complex assembly |
TOP2A | Topoisomerase (DNA) II alpha 170kDa | DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis |
TPX2 | TPX2, microtubule-associated, homolog (Xenopus laevis) | mitosis |
TRIP13 | thyroid hormone receptor interactor 13 | double-strand break repair, transcription from RNA polymerase II promoter |
UBE2C | ubiquitin-conjugating enzyme E2C | spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
Mouse and human tumor signature associated with poor prognosis2: 26-gene sinature | ||
AURKA* | aurora kinase A | mitotic cell cycle, spindle organization |
AURKB | aurora kinase B | mitosis, protein localization to kinetochore |
BIRC5* | baculoviral IAP repeat-containing 5 | microtubule cytoskeleton organization, chromosome segregation, spindle checkpoint |
BUB1* | budding uninhibited by benzimidazoles 1 homolog (yeast) | mitotic cell cycle spindle assembly checkpoint |
BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | apoptosis, mitotic cell cycle checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
CCNA2* | cyclin A2 | mitotic cell cycle G2/M transition DNA damage checkpoint, response to estradiol and glucagon stimulus |
CDC2* | Cell division cycle 2, G1 to S and G2 to M | APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
CDC20* | cell division cycle 20 homolog (S. cerevisiae) | APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
CDKN3* | cyclin-dependent kinase inhibitor 3 | regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle |
CENPA* | centromere protein A | establishment of mitotic spindle orientation, nucleosome assembly |
CHEK1* | CHK1 checkpoint homolog (S. pombe) | DNA damage checkpoint, G2/M transition of mitotic cell cycle |
CKS1B | CDC28 protein kinase regulatory subunit 1B | regulation of cyclin-dependent protein kinase activity |
CKS2* | CDC28 protein kinase regulatory subunit 2 | regulation of cyclin-dependent protein kinase activity, spindle organization |
H2AFZ | H2A histone family, member Z | nucleosome assembly |
HMMR* | hyaluronan-mediated motility receptor (RHAMM) | receptor activity, hyaluronic acid binding |
KIF11 | kinesin family member 11 | mitotic centrosome separation, spindle pole body organization |
KIF2C* | kinesin family member 2C | establishment or maintenance of microtubule cytoskeleton polarity, regulation of chromosome segregation |
KPNA2* | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | regulation of DNA recombination, M phase specific microtubule process, NLS-bearing substrate import into nucleus |
MAD2L1* | MAD2 mitotic arrest deficient-like 1 (yeast) | mitotic cell cycle spindle assembly checkpoint, APC-dependent proteasomal ubiquitin-dependent protein catabolic process |
MCM4* | minichromosome maintenance complex component 4 | DNA replication initiation, regulation of transcription |
NCAPH* | non-SMC condensin I complex, subunit H | mitotic chromosome condensation |
PLK1* | polo-like kinase 1 (Drosophila) | mitotic prometaphase, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle |
PLK4 | polo-like kinase 4 (Drosophila) | positive regulation of centriole replication |
TOP2A* | Topoisomerase (DNA) II alpha 170kDa | DNA replication, topological change, ligation and repair, chromosome segregation, positive regulation of apoptosis |
TPX2* | TPX2, microtubule-associated, homolog (Xenopus laevis) | mitosis |
UBE2C* | ubiquitin-conjugating enzyme E2C | spindle organization, APC-dependent proteasomal ubiquitin-dependent protein catabolic process |