Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Table 3 Plasma expression levels of snoRNAs

SnoRNAs	Twenty-two healthy individuals	Twenty-six COPD patients	Thirty-seven NSCLC patients
	Mean ± SD	Mean ± SD	Mean ± SD
SNORD33	0.1275 ± 0.0631	0.1368 ± 0.0577	0.2466 ± 0.1907 *^‡
SNORD66	0.9821 ± 0.0011	0.9857 ± 0.0015^†	0.9923 ± 0.0035 *^‡
SNORD73B	0.2325 ± 0.0179	0.2297 ± 0.0248	0.2405 ± 0.0363
SNORD76	70.7031 ± 42.2108	64.2773 ± 47.7285	173.1275 ± 52.7852 *^‡
SNORD78	0.3571 ± 0.0186	0.3598 ± 0.0198	0.3613 ± 0.0208
SNORA42	0.0074 ± 0.0016	0.0075 ± 0.0016	0.0076 ± 0.0017

Abbreviations: COPD, chronic obstructive pulmonary disease; NSCLC, non-small-cell lung cancer; SD, standard deviation.
* Statistical significance of expression levels of the snoRNAs between NSCLC patients and healthy controls. P < 0.01.
^† Statistical significance of expression levels of the snoRNA between COPD patients and healthy controls. P < 0.01.
^‡ Statistical significance of expression levels of the snoRNAs between NSCLC patients and COPD patients. P < 0.01.

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