TY - JOUR AU - Gottesman, M. M. AU - Fojo, T. AU - Bates, S. E. PY - 2002 DA - 2002// TI - Multidrug resistance in cancer: role of ATP-dependent transporters JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc706 DO - 10.1038/nrc706 ID - Gottesman2002 ER - TY - JOUR AU - Tsuruo, T. AU - Naito, M. AU - Tomida, A. AU - Fujita, N. AU - Mashima, T. AU - Sakamoto, H. AU - Haga, N. PY - 2003 DA - 2003// TI - Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal JO - Cancer Sci VL - 94 UR - https://doi.org/10.1111/j.1349-7006.2003.tb01345.x DO - 10.1111/j.1349-7006.2003.tb01345.x ID - Tsuruo2003 ER - TY - JOUR AU - Tan, B. AU - Piwnica-Worms, D. AU - Ratner, L. PY - 2000 DA - 2000// TI - Multidrug resistance transporters and modulation JO - Curr Opin Oncol VL - 12 UR - https://doi.org/10.1097/00001622-200009000-00011 DO - 10.1097/00001622-200009000-00011 ID - Tan2000 ER - TY - JOUR AU - Szakacs, G. AU - Paterson, J. K. AU - Ludwig, J. A. AU - Booth-Genthe, C. AU - Gottesman, M. M. PY - 2006 DA - 2006// TI - Targeting multidrug resistance in cancer JO - Nat Rev Drug Discov VL - 5 UR - https://doi.org/10.1038/nrd1984 DO - 10.1038/nrd1984 ID - Szakacs2006 ER - TY - JOUR AU - Trock, B. J. AU - Leonessa, F. AU - Clarke, R. PY - 1997 DA - 1997// TI - Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance JO - J Natl Cancer Inst VL - 89 UR - https://doi.org/10.1093/jnci/89.13.917 DO - 10.1093/jnci/89.13.917 ID - Trock1997 ER - TY - JOUR AU - Norgaard, J. M. AU - Bukh, A. AU - Langkjer, S. T. AU - Clausen, N. AU - Palshof, T. AU - Hokland, P. PY - 1998 DA - 1998// TI - MDR1 gene expression and drug resistance of AML cells JO - Br J Haematol VL - 100 UR - https://doi.org/10.1046/j.1365-2141.1998.00593.x DO - 10.1046/j.1365-2141.1998.00593.x ID - Norgaard1998 ER - TY - JOUR AU - Steinbach, D. AU - Legrand, O. PY - 2007 DA - 2007// TI - ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra? JO - Leukemia VL - 21 UR - https://doi.org/10.1038/sj.leu.2404692 DO - 10.1038/sj.leu.2404692 ID - Steinbach2007 ER - TY - JOUR AU - Ivy, S. P. AU - Olshefski, R. S. AU - Taylor, B. J. AU - Patel, K. M. AU - Reaman, G. H. PY - 1996 DA - 1996// TI - Correlation of P-glycoprotein expression and function in childhood acute leukemia: a children's cancer group study JO - Blood VL - 88 ID - Ivy1996 ER - TY - JOUR AU - Li, X. AU - Li, J. P. AU - Yuan, H. Y. AU - Gao, X. AU - Qu, X. J. AU - Xu, W. F. AU - Tang, W. PY - 2007 DA - 2007// TI - Recent advances in P-glycoprotein-mediated multidrug resistance reversal mechanisms JO - Methods Find Exp Clin Pharmacol VL - 29 UR - https://doi.org/10.1358/mf.2007.29.9.1139054 DO - 10.1358/mf.2007.29.9.1139054 ID - Li2007 ER - TY - JOUR AU - Kim, S. H. AU - Um, J. H. AU - Dong-Won, B. AU - Kwon, B. H. AU - Kim, D. W. AU - Chung, B. S. AU - Kang, C. D. PY - 2000 DA - 2000// TI - Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin JO - Leuk Res VL - 24 UR - https://doi.org/10.1016/S0145-2126(00)00061-8 DO - 10.1016/S0145-2126(00)00061-8 ID - Kim2000 ER - TY - JOUR AU - Bolderson, E. AU - Richard, D. J. AU - Zhou, B. B. AU - Khanna, K. K. PY - 2009 DA - 2009// TI - Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-09-0096 DO - 10.1158/1078-0432.CCR-09-0096 ID - Bolderson2009 ER - TY - JOUR AU - Zhong, X. AU - Safa, A. R. PY - 2007 DA - 2007// TI - Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells JO - Biochemistry VL - 46 UR - https://doi.org/10.1021/bi700063b DO - 10.1021/bi700063b ID - Zhong2007 ER - TY - JOUR AU - West, K. A. AU - Castillo, S. S. AU - Dennis, P. A. PY - 2002 DA - 2002// TI - Activation of the PI3K/Akt pathway and chemotherapeutic resistance JO - Drug Resist Updat VL - 5 UR - https://doi.org/10.1016/S1368-7646(02)00120-6 DO - 10.1016/S1368-7646(02)00120-6 ID - West2002 ER - TY - JOUR AU - Chiarini, F. AU - Del Sole, M. AU - Mongiorgi, S. AU - Gaboardi, G. C. AU - Cappellini, A. AU - Mantovani, I. AU - Follo, M. Y. AU - McCubrey, J. A. AU - Martelli, A. M. PY - 2008 DA - 2008// TI - The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism JO - Leukemia VL - 22 UR - https://doi.org/10.1038/leu.2008.79 DO - 10.1038/leu.2008.79 ID - Chiarini2008 ER - TY - JOUR AU - Choi, B. H. AU - Kim, C. G. AU - Lim, Y. AU - Shin, S. Y. AU - Lee, Y. H. PY - 2008 DA - 2008// TI - Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway JO - Cancer Lett VL - 259 UR - https://doi.org/10.1016/j.canlet.2007.10.003 DO - 10.1016/j.canlet.2007.10.003 ID - Choi2008 ER - TY - JOUR AU - Zhang, Y. AU - Qu, X. AU - Hu, X. AU - Yang, X. AU - Hou, K. AU - Teng, Y. AU - Zhang, J. AU - Sada, K. AU - Liu, Y. PY - 2009 DA - 2009// TI - Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells JO - J Pathol VL - 218 UR - https://doi.org/10.1002/path.2533 DO - 10.1002/path.2533 ID - Zhang2009 ER - TY - JOUR AU - Bozulic, L. AU - Surucu, B. AU - Hynx, D. AU - Hemmings, B. A. PY - 2008 DA - 2008// TI - PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival JO - Mol Cell VL - 30 UR - https://doi.org/10.1016/j.molcel.2008.02.024 DO - 10.1016/j.molcel.2008.02.024 ID - Bozulic2008 ER - TY - JOUR AU - Feng, J. AU - Park, J. AU - Cron, P. AU - Hess, D. AU - Hemmings, B. A. PY - 2004 DA - 2004// TI - Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M406731200 DO - 10.1074/jbc.M406731200 ID - Feng2004 ER - TY - JOUR AU - Beurel, E. AU - Jope, R. S. PY - 2006 DA - 2006// TI - The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways JO - Prog Neurobiol VL - 79 UR - https://doi.org/10.1016/j.pneurobio.2006.07.006 DO - 10.1016/j.pneurobio.2006.07.006 ID - Beurel2006 ER - TY - JOUR AU - Srivastava, R. K. PY - 2001 DA - 2001// TI - TRAIL/Apo-2L: mechanisms and clinical applications in cancer JO - Neoplasia VL - 3 UR - https://doi.org/10.1038/sj.neo.7900203 DO - 10.1038/sj.neo.7900203 ID - Srivastava2001 ER - TY - JOUR AU - Falschlehner, C. AU - Emmerich, C. H. AU - Gerlach, B. AU - Walczak, H. PY - 2007 DA - 2007// TI - TRAIL signalling: decisions between life and death JO - Int J Biochem Cell Biol VL - 39 UR - https://doi.org/10.1016/j.biocel.2007.02.007 DO - 10.1016/j.biocel.2007.02.007 ID - Falschlehner2007 ER - TY - JOUR AU - Day, T. W. AU - Huang, S. AU - Safa, A. R. PY - 2008 DA - 2008// TI - c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells JO - Biochem Pharmacol VL - 76 UR - https://doi.org/10.1016/j.bcp.2008.09.007 DO - 10.1016/j.bcp.2008.09.007 ID - Day2008 ER - TY - JOUR AU - Nam, S. Y. AU - Amoscato, A. A. AU - Lee, Y. J. PY - 2002 DA - 2002// TI - Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway JO - Oncogene VL - 21 UR - https://doi.org/10.1038/sj.onc.1205068 DO - 10.1038/sj.onc.1205068 ID - Nam2002 ER - TY - JOUR AU - Cenni, V. AU - Maraldi, N. M. AU - Ruggeri, A. AU - Secchiero, P. AU - Del Coco, R. AU - De Pol, A. AU - Cocco, L. AU - Marmiroli, S. PY - 2004 DA - 2004// TI - Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase JO - Int J Oncol VL - 25 ID - Cenni2004 ER - TY - JOUR AU - Park, S. J. AU - Wu, C. H. AU - Choi, M. R. AU - Najafi, F. AU - Emami, A. AU - Safa, A. R. PY - 2006 DA - 2006// TI - P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5 JO - Biochem Pharmacol VL - 72 UR - https://doi.org/10.1016/j.bcp.2006.04.024 DO - 10.1016/j.bcp.2006.04.024 ID - Park2006 ER - TY - JOUR AU - Krishna, R. AU - Mayer, L. D. PY - 2000 DA - 2000// TI - Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs JO - Eur J Pharm Sci VL - 11 UR - https://doi.org/10.1016/S0928-0987(00)00114-7 DO - 10.1016/S0928-0987(00)00114-7 ID - Krishna2000 ER - TY - JOUR AU - Safa, A. R. AU - Day, T. W. AU - Wu, C. H. PY - 2008 DA - 2008// TI - Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy JO - Curr Cancer Drug Targets VL - 8 UR - https://doi.org/10.2174/156800908783497087 DO - 10.2174/156800908783497087 ID - Safa2008 ER - TY - JOUR AU - An, J. AU - Yang, D. Y. AU - Xu, Q. Z. AU - Zhang, S. M. AU - Huo, Y. Y. AU - Shang, Z. F. AU - Wang, Y. AU - Wu, D. C. AU - Zhou, P. K. PY - 2008 DA - 2008// TI - DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein JO - Mol Cancer VL - 7 UR - https://doi.org/10.1186/1476-4598-7-32 DO - 10.1186/1476-4598-7-32 ID - An2008 ER - TY - JOUR AU - Nakamura, Y. AU - Sato, H. AU - Motokura, T. PY - 2006 DA - 2006// TI - Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation JO - Int J Cancer VL - 118 UR - https://doi.org/10.1002/ijc.21691 DO - 10.1002/ijc.21691 ID - Nakamura2006 ER - TY - JOUR AU - He, Y. AU - Zhang, J. AU - Yuan, Y. PY - 2000 DA - 2000// TI - The role of c-myc in regulating mdr1 gene expression in tumor cell line KB JO - Chin Med J (Engl) VL - 113 ID - He2000 ER - TY - JOUR AU - Klefstrom, J. AU - Verschuren, E. W. AU - Evan, G. PY - 2002 DA - 2002// TI - c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M206967200 DO - 10.1074/jbc.M206967200 ID - Klefstrom2002 ER - TY - JOUR AU - Zhang, J. AU - Hawkins, S. F. AU - Glenn, M. A. AU - Lin, K. AU - Johnson, G. G. AU - Carter, A. AU - Cawley, J. C. AU - Pettitt, A. R. PY - 2010 DA - 2010// TI - Akt is activated in chronic lymhocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition JO - Haematologica VL - 95 UR - https://doi.org/10.3324/haematol.2009.010272 DO - 10.3324/haematol.2009.010272 ID - Zhang2010 ER - TY - JOUR AU - Mantovani, I. AU - Cappellini, A. AU - Tazzari, P. L. AU - Papa, V. AU - Cocco, L. AU - Martelli, A. M. PY - 2006 DA - 2006// TI - Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells JO - J Cell Physiol VL - 207 UR - https://doi.org/10.1002/jcp.20628 DO - 10.1002/jcp.20628 ID - Mantovani2006 ER - TY - JOUR AU - Affar, E. B. AU - Germain, M. AU - Winstall, E. AU - Vodenicharov, M. AU - Shah, R. G. AU - Salvesen, G. S. AU - Poirier, G. G. PY - 2001 DA - 2001// TI - Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M007269200 DO - 10.1074/jbc.M007269200 ID - Affar2001 ER - TY - JOUR AU - Graham, K. L. AU - Gustin, K. E. AU - Rivera, C. AU - Kuyumcu-Martinez, N. M. AU - Choe, S. S. AU - Lloyd, R. E. AU - Sarnow, P. AU - Utz, P. J. PY - 2004 DA - 2004// TI - Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection JO - J Virol VL - 78 UR - https://doi.org/10.1128/JVI.78.12.6313-6321.2004 DO - 10.1128/JVI.78.12.6313-6321.2004 ID - Graham2004 ER - TY - JOUR AU - Park, S. J. AU - Kim, M. J. AU - Kim, H. B. AU - Sohn, H. Y. AU - Bae, J. H. AU - Kang, C. D. AU - Kim, S. H. PY - 2009 DA - 2009// TI - Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells JO - Exp Cell Res VL - 315 UR - https://doi.org/10.1016/j.yexcr.2009.02.024 DO - 10.1016/j.yexcr.2009.02.024 ID - Park2009 ER - TY - JOUR AU - Lee, N. S. AU - Cheong, H. J. AU - Kim, S. J. AU - Kim, S. E. AU - Kim, C. K. AU - Lee, K. T. AU - Park, S. K. AU - Baick, S. H. AU - Hong, D. S. AU - Park, H. S. AU - Won, J. H. PY - 2003 DA - 2003// TI - Ex vivo purging of leukemia cells using tumor-necrosis-factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation JO - Leukemia VL - 17 UR - https://doi.org/10.1038/sj.leu.2402960 DO - 10.1038/sj.leu.2402960 ID - Lee2003 ER - TY - JOUR AU - Nakamura, H. AU - Kawakami, A. AU - Iwamoto, N. AU - Ida, H. AU - Koji, T. AU - Eguchi, K. PY - 2008 DA - 2008// TI - Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjogren's syndrome JO - Apoptosis VL - 13 UR - https://doi.org/10.1007/s10495-008-0261-2 DO - 10.1007/s10495-008-0261-2 ID - Nakamura2008 ER - TY - JOUR AU - Wang, Y. AU - Engels, I. H. AU - Knee, D. A. AU - Nasoff, M. AU - Deveraux, Q. L. AU - Quon, K. C. PY - 2004 DA - 2004// TI - Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway JO - Cancer Cell VL - 5 UR - https://doi.org/10.1016/S1535-6108(04)00113-8 DO - 10.1016/S1535-6108(04)00113-8 ID - Wang2004 ER - TY - JOUR AU - Ricci, M. S. AU - Jin, Z. AU - Dews, M. AU - Yu, D. AU - Thomas-Tikhonenko, A. AU - Dicker, D. T. AU - El-Deiry, W. S. PY - 2004 DA - 2004// TI - Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.19.8541-8555.2004 DO - 10.1128/MCB.24.19.8541-8555.2004 ID - Ricci2004 ER - TY - JOUR AU - Han, Z. AU - Hong, L. AU - Han, Y. AU - Wu, K. AU - Han, S. AU - Shen, H. AU - Li, C. AU - Yao, L. AU - Qiao, T. AU - Fan, D. PY - 2007 DA - 2007// TI - Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax JO - J Exp Clin Cancer Res VL - 26 ID - Han2007 ER - TY - JOUR AU - Lim, J. C. AU - Kania, K. D. AU - Wijesuriya, H. AU - Chawla, S. AU - Sethi, J. K. AU - Pulaski, L. AU - Romero, I. A. AU - Couraud, P. O. AU - Weksler, B. B. AU - Hladky, S. B. AU - Barrand, M. A. PY - 2008 DA - 2008// TI - Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells JO - J Neurochem VL - 106 ID - Lim2008 ER - TY - JOUR AU - David, E. AU - Sinha, R. AU - Chen, J. AU - Sun, S. Y. AU - Kaufman, J. L. AU - Lonial, S. PY - 2008 DA - 2008// TI - Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors JO - Clin Cancer Res VL - 14 UR - https://doi.org/10.1158/1078-0432.CCR-08-0016 DO - 10.1158/1078-0432.CCR-08-0016 ID - David2008 ER - TY - JOUR AU - Nam, S. Y. AU - Jung, G. A. AU - Hur, G. C. AU - Chung, H. Y. AU - Kim, W. H. AU - Seol, D. W. AU - Lee, B. L. PY - 2003 DA - 2003// TI - Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers JO - Cancer Sci VL - 94 UR - https://doi.org/10.1111/j.1349-7006.2003.tb01402.x DO - 10.1111/j.1349-7006.2003.tb01402.x ID - Nam2003 ER - TY - JOUR AU - Gul, O. AU - Basaga, H. AU - Kutuk, O. PY - 2008 DA - 2008// TI - Apoptotic blocks and chemotherapy resistance: strategies to identify Bcl-2 protein signatures JO - Brief Funct Genomic Proteomic VL - 7 UR - https://doi.org/10.1093/bfgp/eln002 DO - 10.1093/bfgp/eln002 ID - Gul2008 ER - TY - JOUR AU - Del Poeta, G. AU - Bruno, A. AU - Del Principe, M. I. AU - Venditti, A. AU - Maurillo, L. AU - Buccisano, F. AU - Stasi, R. AU - Neri, B. AU - Luciano, F. AU - Siniscalchi, A. PY - 2008 DA - 2008// TI - Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia JO - Curr Cancer Drug Targets VL - 8 UR - https://doi.org/10.2174/156800908784293640 DO - 10.2174/156800908784293640 ID - Del Poeta2008 ER - TY - JOUR AU - Nuessler, V. AU - Stotzer, O. AU - Gullis, E. AU - Pelka-Fleischer, R. AU - Pogrebniak, A. AU - Gieseler, F. AU - Wilmanns, W. PY - 1999 DA - 1999// TI - Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines JO - Leukemia VL - 13 UR - https://doi.org/10.1038/sj.leu.2401571 DO - 10.1038/sj.leu.2401571 ID - Nuessler1999 ER - TY - JOUR AU - Ji, M. AU - Li, J. AU - Yu, H. AU - Ma, D. AU - Ye, J. AU - Sun, X. AU - Ji, C. PY - 2009 DA - 2009// TI - Simultaneous targeting of MCL1 and ABCB1 as a novel strategy to overcome drug resistance in human leukaemia JO - Br J Haematol VL - 145 UR - https://doi.org/10.1111/j.1365-2141.2009.07678.x DO - 10.1111/j.1365-2141.2009.07678.x ID - Ji2009 ER -