Table 1 Top 30 genes up- or downregulated statistically significant more than 2-fold in BeWo control (LMP) cells compared with cells deficient in HO-1 (miHO-1)
Probe Set ID | Mean Fold Change (LMP vs miHO-1) | Adj. P-Value | Gene Symbol | Gene Name |
|---|---|---|---|---|
Upregulated in HO-1 expressing control (LMP) cells: | ||||
NM_005330_at | 7,82 | 0,0073 | HBE1 | hemoglobin, epsilon 1 |
NM_024913_at | 7,74 | 0,0067 | C7orf58 | chromosome 7 open reading frame 58 |
NM_001105533_at | 5,56 | 0,0073 | C7orf58 | chromosome 7 open reading frame 58 |
NM_206828_at | 5,10 | 0,0077 | NLRP7 | NLR family, pyrin domain containing 7 |
NM_002133_at | 5,09 | 0,0262 | HMOX1 | heme oxygenase (decycling) 1 |
NM_139176_at | 4,90 | 0,0081 | NLRP7 | NLR family, pyrin domain containing 7 |
NM_004530_at | 4,83 | 0,0098 | MMP2 | matrix metallopeptidase 2 (gelatinase A) |
XM_001720850_at | 4,48 | 0,0092 | LOC100134134 | similar to peroxidasin homolog |
NM_030820_at | 4,34 | 0,0223 | COL21A1 | collagen, type XXI, alpha 1 |
NM_012293_at | 4,27 | 0,0092 | PXDN | peroxidasin homolog (Drosophila) |
XM_001715515_at | 3,86 | 0,0106 | LOC100131375 | similar to peroxidasin homolog |
NM_000660_at | 3,60 | 0,0306 | TGFB1 | transforming growth factor, beta 1 |
NM_001312_at | 3,39 | 0,0146 | CRIP2 | cysteine-rich protein 2 |
NM_004425_at | 2,99 | 0,0262 | ECM1 | extracellular matrix protein 1 |
NM_006227_at | 2,91 | 0,0306 | PLTP | phospholipid transfer protein |
NM_182676_at | 2,91 | 0,0306 | PLTP | phospholipid transfer protein |
XM_001718318_at | 2,91 | 0,0318 | LOC100131307 | hypothetical protein LOC100131307 |
NM_000413_at | 2,88 | 0,0262 | HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 |
NM_178422_at | 2,87 | 0,0301 | PAQR7 | progestin and adipoQ receptor family member VII |
NM_022664_at | 2,86 | 0,0262 | ECM1 | extracellular matrix protein 1 |
NM_001109_at | 2,76 | 0,0284 | ADAM8 | ADAM metallopeptidase domain 8 |
NM_000391_at | 2,64 | 0,0306 | TPP1 | tripeptidyl peptidase I |
XM_001726123_at | 2,64 | 0,0262 | LOC100133842 | similar to lectin, galactoside-binding, soluble, 3 binding protein |
NM_003045_at | 2,63 | 0,0262 | SLC7A1 | solute carrier family 7, member 1 |
NM_005931_at | 2,63 | 0,0231 | MICB | MHC class I polypeptide-related sequence B |
NM_000041_at | 2,61 | 0,0262 | APOE | apolipoprotein E |
NM_006927_at | 2,60 | 0,0262 | ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
NM_001042423_at | 2,60 | 0,0334 | SLC16A3 | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
NM_004207_at | 2,59 | 0,0332 | SLC16A3 | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
downregulated in HO-1 expressing control (LMP) cells: | ||||
NM_013230_at | -22,27 | 0,0067 | CD24 | CD24 molecule |
XM_001725629_at | -19,19 | 0,0067 | CD24 | CD24 molecule |
NM_003810_at | -14,22 | 0,0067 | TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
NM_032812_at | -6,27 | 0,0072 | PLXDC2 | plexin domain containing 2 |
XM_001726122_at | -3,66 | 0,0206 | FLJ32810 | hypothetical protein FLJ32810 |
NM_006982_at | -3,37 | 0,0155 | ALX1 | ALX homeobox 1 |
NM_015888_at | -3,34 | 0,0262 | HOOK1 | hook homolog 1 (Drosophila) |
NM_178834_at | -3,34 | 0,0315 | LAYN | layilin |
NM_003063_at | -3,27 | 0,0262 | SLN | sarcolipin |
NM_030972_at | -3,25 | 0,0178 | ZNF611 | zinc finger protein 611 |
NM_032021_at | -3,15 | 0,0178 | TMEM133 | transmembrane protein 133 |
NM_005028_at | -3,14 | 0,0206 | PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha |
XM_001715384_at | -3,09 | 0,0256 | LOC100134369 | similar to golgi phosphoprotein 2 |
NM_017423_at | -3,06 | 0,0262 | GALNT7 | N-acetylgalactosaminyltransferase 7 |
NM_001008401_at | -3,00 | 0,0306 | ZNF761 | zinc finger protein 761 |
XM_001127597_at | -2,98 | 0,0178 | FLJ32810 | hypothetical protein FLJ32810 |
NM_030925_at | -2,95 | 0,0178 | CAB39L | calcium binding protein 39-like |
NM_001079670_at | -2,92 | 0,0178 | CAB39L | calcium binding protein 39-like |
NM_001726_at | -2,88 | 0,0297 | BRDT | bromodomain, testis-specific |
NM_177937_at | -2,87 | 0,0178 | GOLM1 | golgi membrane protein 1 |
NM_014827_at | -2,81 | 0,0321 | ZC3H11A | zinc finger CCCH-type containing 11A |
NM_001042482_at | -2,78 | 0,0306 | TPK1 | thiamin pyrophosphokinase 1 |
NM_004052_at | -2,77 | 0,0306 | BNIP3 | BCL2/adenovirus E1B 19 kDa interacting protein 3 |
NM_006424_at | -2,75 | 0,0262 | SLC34A2 | solute carrier family 34 (sodium phosphate), member 2 |
NM_005900_at | -2,73 | 0,0262 | SMAD1 | SMAD family member 1 |
NM_001008397_at | -2,72 | 0,0262 | GPX8 | glutathione peroxidase 8 |
NM_018169_at | -2,71 | 0,0284 | C12orf35 | chromosome 12 open reading frame 35 |
NR_003942_at | -2,68 | 0,0318 | SNORD76 | small nucleolar RNA, C/D box 76 |
XM_001726844_at | -2,66 | 0,0375 | LOC100130123 | PRO2870 |
NM_207189_at | -2,65 | 0,0276 | BRDT | bromodomain, testis-specific |