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Table 1 RNA expression of proteases and matrix components in response to longterm HERmrk stimulation.

From: MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation

gene

ENSEMBL reference

induction by HERmrk

Mmp1a

ENSMUSG00000043089

+++

Mmp1b

ENSMUSG00000041620

+++

Mmp3

ENSMUSG00000043613

+++

Mmp7

ENSMUSG00000018623

-

Mmp8

ENSMUSG00000005800

-

Mmp9

ENSMUSG00000017737

+

Mmp11

ENSMUSG00000000901

-

Mmp13

ENSMUSG00000050578

++

Mmp14

ENSMUSG00000000957

-

Mmp15

ENSMUSG00000031790

-

Mmp16

ENSMUSG00000028226

-

Mmp24

ENSMUSG00000027612

-

Upa

ENSMUSG00000021822

-

CatD

ENSMUSG00000007891

-

CatL

ENSMUSG00000021477

-

Col1

ENSMUSG00000001506

-

Col4

ENSMUSG00000031502

-

Lam

ENSMUSG00000032796

-

Fn1

ENSMUSG00000026193

-

  1. The highest induction of Mmp1a, -1b, -3, -9 and -13 was seen at 8 h after EGF induction. The symbols given in the table refer to gene induction at this timepoint. +: induction 2-20-fold; ++: induction 20-100-fold; +++: induction >100-fold.
  2. Upa: urokinase plasminogen activator; CatD: cathepsin D; CatL: cathepsin L; Col1: collagen I; Col4: collagen IV, Lam: laminin; Fn1: fibronectin I.
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Molecular Cancer

ISSN: 1476-4598