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Figure 3 | Molecular Cancer

Figure 3

From: Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations

Figure 3

Box plot of TRAIL, TRAIL-R1 and TRAILR2 expression in cancer, adenoma, and normal samples of colorectal patients. (A) Using Student's t-test, the mean ± SD of TRAIL expression in normal colorectal mucosa (48.59 ± 66.07), adenoma (129.01 ± 38.59) and cancer (132.87 ± 64.23) and showed a significant association with cancer versus normal (p < 0.0001) and adenoma versus normal (p < 0.0001). (B) Using Student's t-test, the mean ± SD of TRAIL-R1 expression in normal colorectal mucosa (52.13 ± 42.48), adenoma (96.11 ± 78.82), cancer (173.91 ± 61.20) showed a significant association with cancer versus normal (p < 0.0001), adenoma versus normal(p = 0.0312) and adenoma versus cancer(p = 0.0006). (C) Using Student's t-test, the mean ± SD of TRAIL-R2 expression in normal colorectal mucosa (24.57 ± 38.77), adenoma (59.17 ± 49.69) and cancer (115.63 ± 95.76) showed a significant association with cancer versus normal (p < 0.0001), adenoma versus normal(p = 0.0027) and adenoma versus cancer(p < 0.0001).

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Molecular Cancer

ISSN: 1476-4598